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Association of serum liver enzyme Alanine Aminotransferase (ALT) in patients with type 2 diabetes

OBJECTIVES: To assess the association of raised serum liver enzyme (ALT) with type 2 diabetic subjects. METHODS: This retrospective data was accessed at Baqai Institute of Diabetology and Endocrinology (BIDE) from January 2005 to May 2016. A total of 1966 subjects with type 2 diabetes were included...

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Autores principales: Abro, Mujeeb Ur Rehman, Butt, Anum, Baqa, Kulsoom, Waris, Nazish, Khalid, Maria, Fawwad, Asher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115576/
https://www.ncbi.nlm.nih.gov/pubmed/30190738
http://dx.doi.org/10.12669/pjms.344.15206
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author Abro, Mujeeb Ur Rehman
Butt, Anum
Baqa, Kulsoom
Waris, Nazish
Khalid, Maria
Fawwad, Asher
author_facet Abro, Mujeeb Ur Rehman
Butt, Anum
Baqa, Kulsoom
Waris, Nazish
Khalid, Maria
Fawwad, Asher
author_sort Abro, Mujeeb Ur Rehman
collection PubMed
description OBJECTIVES: To assess the association of raised serum liver enzyme (ALT) with type 2 diabetic subjects. METHODS: This retrospective data was accessed at Baqai Institute of Diabetology and Endocrinology (BIDE) from January 2005 to May 2016. A total of 1966 subjects with type 2 diabetes were included in the study. Subjects were divided into two groups; in group A 1284 subjects had ALT within the normal range (ALT≤35iu/l) and in Group-B 682 subjects had elevated ALT (ALT>35iu/l). Details of demographics, anthropometric measurements and biochemical results at baseline were extracted from the health management system of BIDE. Data analysis was conducted on Statistical Package for Social Sciences (SPSS) version 20. RESULTS: Out of 1966 type 2 diabetic subjects 1284(65.4%) were observed with normal value of ALT (≤35) and 682(34.6%) with elevated ALT (>35). Overall mean age of subjects was 54.66±10.98 years and mean BMI was 27.34±5.99 kg/m(2). Significant difference was observed between the groups in age (if ALT>35), gender (more likely to be male) and triglyceride (higher if ALT>35).Whereas no significant difference was found between the groups in HbA1c, cholesterol, HDL and LDL. CONCLUSION: High frequency of elevated ALT suggests the association of liver disease with type 2 diabetes. The type 2 diabetic subjects need to be routinely screened and further studies to assess the possible associations with NAFLD and insulin resistance are required to further clarify the disease process.
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spelling pubmed-61155762018-09-06 Association of serum liver enzyme Alanine Aminotransferase (ALT) in patients with type 2 diabetes Abro, Mujeeb Ur Rehman Butt, Anum Baqa, Kulsoom Waris, Nazish Khalid, Maria Fawwad, Asher Pak J Med Sci Original Article OBJECTIVES: To assess the association of raised serum liver enzyme (ALT) with type 2 diabetic subjects. METHODS: This retrospective data was accessed at Baqai Institute of Diabetology and Endocrinology (BIDE) from January 2005 to May 2016. A total of 1966 subjects with type 2 diabetes were included in the study. Subjects were divided into two groups; in group A 1284 subjects had ALT within the normal range (ALT≤35iu/l) and in Group-B 682 subjects had elevated ALT (ALT>35iu/l). Details of demographics, anthropometric measurements and biochemical results at baseline were extracted from the health management system of BIDE. Data analysis was conducted on Statistical Package for Social Sciences (SPSS) version 20. RESULTS: Out of 1966 type 2 diabetic subjects 1284(65.4%) were observed with normal value of ALT (≤35) and 682(34.6%) with elevated ALT (>35). Overall mean age of subjects was 54.66±10.98 years and mean BMI was 27.34±5.99 kg/m(2). Significant difference was observed between the groups in age (if ALT>35), gender (more likely to be male) and triglyceride (higher if ALT>35).Whereas no significant difference was found between the groups in HbA1c, cholesterol, HDL and LDL. CONCLUSION: High frequency of elevated ALT suggests the association of liver disease with type 2 diabetes. The type 2 diabetic subjects need to be routinely screened and further studies to assess the possible associations with NAFLD and insulin resistance are required to further clarify the disease process. Professional Medical Publications 2018 /pmc/articles/PMC6115576/ /pubmed/30190738 http://dx.doi.org/10.12669/pjms.344.15206 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Abro, Mujeeb Ur Rehman
Butt, Anum
Baqa, Kulsoom
Waris, Nazish
Khalid, Maria
Fawwad, Asher
Association of serum liver enzyme Alanine Aminotransferase (ALT) in patients with type 2 diabetes
title Association of serum liver enzyme Alanine Aminotransferase (ALT) in patients with type 2 diabetes
title_full Association of serum liver enzyme Alanine Aminotransferase (ALT) in patients with type 2 diabetes
title_fullStr Association of serum liver enzyme Alanine Aminotransferase (ALT) in patients with type 2 diabetes
title_full_unstemmed Association of serum liver enzyme Alanine Aminotransferase (ALT) in patients with type 2 diabetes
title_short Association of serum liver enzyme Alanine Aminotransferase (ALT) in patients with type 2 diabetes
title_sort association of serum liver enzyme alanine aminotransferase (alt) in patients with type 2 diabetes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115576/
https://www.ncbi.nlm.nih.gov/pubmed/30190738
http://dx.doi.org/10.12669/pjms.344.15206
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