Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes

A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an in situ formed copper hydride. A variety of allyl electrophiles could be utilized yielding a diverse range of trisubstituted cyclopropanes. Finally a...

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Detalles Bibliográficos
Autores principales: Sommer, Heiko, Marek, Ilan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115688/
https://www.ncbi.nlm.nih.gov/pubmed/30310580
http://dx.doi.org/10.1039/c8sc02085j
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author Sommer, Heiko
Marek, Ilan
author_facet Sommer, Heiko
Marek, Ilan
author_sort Sommer, Heiko
collection PubMed
description A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an in situ formed copper hydride. A variety of allyl electrophiles could be utilized yielding a diverse range of trisubstituted cyclopropanes. Finally a preliminary enantioselective variant could be established employing a recently described P-stereogenic xantphos derivative as ligand.
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spelling pubmed-61156882018-10-11 Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes Sommer, Heiko Marek, Ilan Chem Sci Chemistry A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an in situ formed copper hydride. A variety of allyl electrophiles could be utilized yielding a diverse range of trisubstituted cyclopropanes. Finally a preliminary enantioselective variant could be established employing a recently described P-stereogenic xantphos derivative as ligand. Royal Society of Chemistry 2018-07-02 /pmc/articles/PMC6115688/ /pubmed/30310580 http://dx.doi.org/10.1039/c8sc02085j Text en This journal is © The Royal Society of Chemistry 2018 https://creativecommons.org/licenses/by-nc/3.0/This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Sommer, Heiko
Marek, Ilan
Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes
title Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes
title_full Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes
title_fullStr Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes
title_full_unstemmed Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes
title_short Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes
title_sort diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115688/
https://www.ncbi.nlm.nih.gov/pubmed/30310580
http://dx.doi.org/10.1039/c8sc02085j
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AT marekilan diastereoandenantioselectivecoppercatalyzedhydroallylationofdisubstitutedcyclopropenes

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