Cargando…

Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms

In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by...

Descripción completa

Detalles Bibliográficos
Autores principales: Venkatesulu, Bhanu Prasad, Mahadevan, Lakshmi Shree, Aliru, Maureen L., Yang, Xi, Bodd, Monica Himaani, Singh, Pankaj K., Yusuf, Syed Wamique, Abe, Jun-ichi, Krishnan, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115704/
https://www.ncbi.nlm.nih.gov/pubmed/30175280
http://dx.doi.org/10.1016/j.jacbts.2018.01.014
Descripción
Sumario:In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by vascular endothelial injury. Radiation both initiates and accelerates atherosclerosis, leading to vascular events like stroke, coronary artery disease, and peripheral artery disease. Increased levels of proinflammatory cytokines in the blood of long-term survivors of the atomic bomb suggest that radiation evokes a systemic inflammatory state responsible for chronic vascular side effects. In this review, the authors offer an overview of potential mechanisms implicated in radiation-induced vascular injury.