Cargando…

Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms

In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by...

Descripción completa

Detalles Bibliográficos
Autores principales: Venkatesulu, Bhanu Prasad, Mahadevan, Lakshmi Shree, Aliru, Maureen L., Yang, Xi, Bodd, Monica Himaani, Singh, Pankaj K., Yusuf, Syed Wamique, Abe, Jun-ichi, Krishnan, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115704/
https://www.ncbi.nlm.nih.gov/pubmed/30175280
http://dx.doi.org/10.1016/j.jacbts.2018.01.014
_version_ 1783351442205048832
author Venkatesulu, Bhanu Prasad
Mahadevan, Lakshmi Shree
Aliru, Maureen L.
Yang, Xi
Bodd, Monica Himaani
Singh, Pankaj K.
Yusuf, Syed Wamique
Abe, Jun-ichi
Krishnan, Sunil
author_facet Venkatesulu, Bhanu Prasad
Mahadevan, Lakshmi Shree
Aliru, Maureen L.
Yang, Xi
Bodd, Monica Himaani
Singh, Pankaj K.
Yusuf, Syed Wamique
Abe, Jun-ichi
Krishnan, Sunil
author_sort Venkatesulu, Bhanu Prasad
collection PubMed
description In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by vascular endothelial injury. Radiation both initiates and accelerates atherosclerosis, leading to vascular events like stroke, coronary artery disease, and peripheral artery disease. Increased levels of proinflammatory cytokines in the blood of long-term survivors of the atomic bomb suggest that radiation evokes a systemic inflammatory state responsible for chronic vascular side effects. In this review, the authors offer an overview of potential mechanisms implicated in radiation-induced vascular injury.
format Online
Article
Text
id pubmed-6115704
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-61157042018-08-31 Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms Venkatesulu, Bhanu Prasad Mahadevan, Lakshmi Shree Aliru, Maureen L. Yang, Xi Bodd, Monica Himaani Singh, Pankaj K. Yusuf, Syed Wamique Abe, Jun-ichi Krishnan, Sunil JACC Basic Transl Sci STATE-OF-THE-ART REVIEW In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by vascular endothelial injury. Radiation both initiates and accelerates atherosclerosis, leading to vascular events like stroke, coronary artery disease, and peripheral artery disease. Increased levels of proinflammatory cytokines in the blood of long-term survivors of the atomic bomb suggest that radiation evokes a systemic inflammatory state responsible for chronic vascular side effects. In this review, the authors offer an overview of potential mechanisms implicated in radiation-induced vascular injury. Elsevier 2018-08-28 /pmc/articles/PMC6115704/ /pubmed/30175280 http://dx.doi.org/10.1016/j.jacbts.2018.01.014 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle STATE-OF-THE-ART REVIEW
Venkatesulu, Bhanu Prasad
Mahadevan, Lakshmi Shree
Aliru, Maureen L.
Yang, Xi
Bodd, Monica Himaani
Singh, Pankaj K.
Yusuf, Syed Wamique
Abe, Jun-ichi
Krishnan, Sunil
Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms
title Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms
title_full Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms
title_fullStr Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms
title_full_unstemmed Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms
title_short Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms
title_sort radiation-induced endothelial vascular injury: a review of possible mechanisms
topic STATE-OF-THE-ART REVIEW
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115704/
https://www.ncbi.nlm.nih.gov/pubmed/30175280
http://dx.doi.org/10.1016/j.jacbts.2018.01.014
work_keys_str_mv AT venkatesulubhanuprasad radiationinducedendothelialvascularinjuryareviewofpossiblemechanisms
AT mahadevanlakshmishree radiationinducedendothelialvascularinjuryareviewofpossiblemechanisms
AT alirumaureenl radiationinducedendothelialvascularinjuryareviewofpossiblemechanisms
AT yangxi radiationinducedendothelialvascularinjuryareviewofpossiblemechanisms
AT boddmonicahimaani radiationinducedendothelialvascularinjuryareviewofpossiblemechanisms
AT singhpankajk radiationinducedendothelialvascularinjuryareviewofpossiblemechanisms
AT yusufsyedwamique radiationinducedendothelialvascularinjuryareviewofpossiblemechanisms
AT abejunichi radiationinducedendothelialvascularinjuryareviewofpossiblemechanisms
AT krishnansunil radiationinducedendothelialvascularinjuryareviewofpossiblemechanisms