Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose

Hepatocytes may rupture after a drug overdose, and their intracellular contents act as damage-associated molecular patterns (DAMPs) that lead to additional leukocyte infiltration, amplifying the original injury. Necrosis-derived DNA can be recognized as a DAMP, activating liver non-parenchymal cells...

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Detalles Bibliográficos
Autores principales: de Araujo, Alan Moreira, Antunes, Maísa Mota, Mattos, Matheus Silvério, Diniz, Ariane Barros, Alvarenga, Débora Moreira, Nakagaki, Brenda Naemi, de Carvalho, Érika, Lacerda, Viviane Aparecida Souza, Carvalho-Gontijo, Raquel, Goulart, Jorge, Mafra, Kassiana, Freitas-Lopes, Maria Alice, Oliveira, Hortência Maciel de Castro, Dutra, Camila Miranda, David, Bruna Araújo, Mendes Silva, Aristóbolo, Quesniaux, Valerie, Ryffel, Bernhard, Oliveira, Sergio Costa, Barber, Glen N., Mansur, Daniel Santos, Cunha, Thiago Mattar, Rezende, Rafael Machado, Oliveira, André Gustavo, Menezes, Gustavo Batista
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115735/
https://www.ncbi.nlm.nih.gov/pubmed/30060463
http://dx.doi.org/10.3390/cells7080088

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