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Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response

Animal studies using tests and models have demonstrated that magnesium exerts an antidepressant effect. The literature contains few studies in humans involving attempts to augment antidepressant therapy with magnesium ions. The purpose of our study was to assess the efficacy and safety of antidepres...

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Autores principales: Ryszewska-Pokraśniewicz, Beata, Mach, Anna, Skalski, Michał, Januszko, Piotr, Wawrzyniak, Zbigniew M., Poleszak, Ewa, Nowak, Gabriel, Pilc, Andrzej, Radziwoń-Zaleska, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115747/
https://www.ncbi.nlm.nih.gov/pubmed/30081500
http://dx.doi.org/10.3390/nu10081014
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author Ryszewska-Pokraśniewicz, Beata
Mach, Anna
Skalski, Michał
Januszko, Piotr
Wawrzyniak, Zbigniew M.
Poleszak, Ewa
Nowak, Gabriel
Pilc, Andrzej
Radziwoń-Zaleska, Maria
author_facet Ryszewska-Pokraśniewicz, Beata
Mach, Anna
Skalski, Michał
Januszko, Piotr
Wawrzyniak, Zbigniew M.
Poleszak, Ewa
Nowak, Gabriel
Pilc, Andrzej
Radziwoń-Zaleska, Maria
author_sort Ryszewska-Pokraśniewicz, Beata
collection PubMed
description Animal studies using tests and models have demonstrated that magnesium exerts an antidepressant effect. The literature contains few studies in humans involving attempts to augment antidepressant therapy with magnesium ions. The purpose of our study was to assess the efficacy and safety of antidepressant treatment, in combination with magnesium ions. A total of 37 participants with recurrent depressive disorder who developed a depressive episode were included in this study. As part of this double-blind study, treatment with the antidepressant fluoxetine was accompanied with either magnesium ions (120 mg/day as magnesium aspartate) or placebo. During an 8-week treatment period, each patient was monitored for any clinical abnormalities. Moreover, serum fluoxetine and magnesium levels were measured, and pharmaco-electroencephalography was performed. The fluoxetine + magnesium and fluoxetine + placebo groups showed no significant differences in either Hamilton Depression Rating Scale (HDRS) scores or serum magnesium levels at any stage of treatment. Multivariate statistical analysis of the whole investigated group showed that the following parameters increased the odds of effective treatment: lower baseline HDRS scores, female gender, smoking, and treatment augmentation with magnesium. The parameters that increased the odds of remission were lower baseline HDRS scores, shorter history of disease, the presence of antidepressant-induced changes in the pharmaco-EEG profile at 6 h after treatment, and the fact of receiving treatment augmented with magnesium ions. The limitation of this study is a small sample size.
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spelling pubmed-61157472018-09-04 Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response Ryszewska-Pokraśniewicz, Beata Mach, Anna Skalski, Michał Januszko, Piotr Wawrzyniak, Zbigniew M. Poleszak, Ewa Nowak, Gabriel Pilc, Andrzej Radziwoń-Zaleska, Maria Nutrients Article Animal studies using tests and models have demonstrated that magnesium exerts an antidepressant effect. The literature contains few studies in humans involving attempts to augment antidepressant therapy with magnesium ions. The purpose of our study was to assess the efficacy and safety of antidepressant treatment, in combination with magnesium ions. A total of 37 participants with recurrent depressive disorder who developed a depressive episode were included in this study. As part of this double-blind study, treatment with the antidepressant fluoxetine was accompanied with either magnesium ions (120 mg/day as magnesium aspartate) or placebo. During an 8-week treatment period, each patient was monitored for any clinical abnormalities. Moreover, serum fluoxetine and magnesium levels were measured, and pharmaco-electroencephalography was performed. The fluoxetine + magnesium and fluoxetine + placebo groups showed no significant differences in either Hamilton Depression Rating Scale (HDRS) scores or serum magnesium levels at any stage of treatment. Multivariate statistical analysis of the whole investigated group showed that the following parameters increased the odds of effective treatment: lower baseline HDRS scores, female gender, smoking, and treatment augmentation with magnesium. The parameters that increased the odds of remission were lower baseline HDRS scores, shorter history of disease, the presence of antidepressant-induced changes in the pharmaco-EEG profile at 6 h after treatment, and the fact of receiving treatment augmented with magnesium ions. The limitation of this study is a small sample size. MDPI 2018-08-03 /pmc/articles/PMC6115747/ /pubmed/30081500 http://dx.doi.org/10.3390/nu10081014 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ryszewska-Pokraśniewicz, Beata
Mach, Anna
Skalski, Michał
Januszko, Piotr
Wawrzyniak, Zbigniew M.
Poleszak, Ewa
Nowak, Gabriel
Pilc, Andrzej
Radziwoń-Zaleska, Maria
Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response
title Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response
title_full Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response
title_fullStr Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response
title_full_unstemmed Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response
title_short Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response
title_sort effects of magnesium supplementation on unipolar depression: a placebo-controlled study and review of the importance of dosing and magnesium status in the therapeutic response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115747/
https://www.ncbi.nlm.nih.gov/pubmed/30081500
http://dx.doi.org/10.3390/nu10081014
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