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Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma

Adherence to the American Cancer Society’s (ACS) Nutrition and Physical Activity Cancer Prevention Guidelines is associated with reductions in overall cancer incidence and mortality, including site-specific cancers such as colorectal cancer. We examined the relationship between baseline adherence to...

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Autores principales: Kohler, Lindsay N., Harris, Robin B., Oren, Eyal, Roe, Denise J., Lance, Peter, Jacobs, Elizabeth T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115749/
https://www.ncbi.nlm.nih.gov/pubmed/30115827
http://dx.doi.org/10.3390/nu10081098
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author Kohler, Lindsay N.
Harris, Robin B.
Oren, Eyal
Roe, Denise J.
Lance, Peter
Jacobs, Elizabeth T.
author_facet Kohler, Lindsay N.
Harris, Robin B.
Oren, Eyal
Roe, Denise J.
Lance, Peter
Jacobs, Elizabeth T.
author_sort Kohler, Lindsay N.
collection PubMed
description Adherence to the American Cancer Society’s (ACS) Nutrition and Physical Activity Cancer Prevention Guidelines is associated with reductions in overall cancer incidence and mortality, including site-specific cancers such as colorectal cancer. We examined the relationship between baseline adherence to the ACS guidelines and (1) baseline adenoma characteristics and (2) odds of recurrent colorectal adenomas over 3 years of follow-up. Cross-sectional and prospective analyses with a pooled sample of participants from the Wheat Bran Fiber (n = 503) and Ursodeoxycholic Acid (n = 854) trials were performed. A cumulative adherence score was constructed using baseline self-reported data regarding body size, diet, physical activity and alcohol consumption. Multivariable logistic regression demonstrated significantly reduced odds of having three or more adenomas at baseline for moderately adherent (odds ratio [OR] = 0.67, 95% confidence intervals [CI]: 0.46–0.99) and highly adherent (OR = 0.50, 95% CI: 0.31–0.81) participants compared to low adherers (p-trend = 0.005). Conversely, guideline adherence was not associated with development of recurrent colorectal adenoma (moderate adherence OR = 1.16, 95% CI: 0.85–1.59, high adherence OR = 1.23, 95% CI: 0.85–1.79).
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spelling pubmed-61157492018-09-04 Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma Kohler, Lindsay N. Harris, Robin B. Oren, Eyal Roe, Denise J. Lance, Peter Jacobs, Elizabeth T. Nutrients Article Adherence to the American Cancer Society’s (ACS) Nutrition and Physical Activity Cancer Prevention Guidelines is associated with reductions in overall cancer incidence and mortality, including site-specific cancers such as colorectal cancer. We examined the relationship between baseline adherence to the ACS guidelines and (1) baseline adenoma characteristics and (2) odds of recurrent colorectal adenomas over 3 years of follow-up. Cross-sectional and prospective analyses with a pooled sample of participants from the Wheat Bran Fiber (n = 503) and Ursodeoxycholic Acid (n = 854) trials were performed. A cumulative adherence score was constructed using baseline self-reported data regarding body size, diet, physical activity and alcohol consumption. Multivariable logistic regression demonstrated significantly reduced odds of having three or more adenomas at baseline for moderately adherent (odds ratio [OR] = 0.67, 95% confidence intervals [CI]: 0.46–0.99) and highly adherent (OR = 0.50, 95% CI: 0.31–0.81) participants compared to low adherers (p-trend = 0.005). Conversely, guideline adherence was not associated with development of recurrent colorectal adenoma (moderate adherence OR = 1.16, 95% CI: 0.85–1.59, high adherence OR = 1.23, 95% CI: 0.85–1.79). MDPI 2018-08-16 /pmc/articles/PMC6115749/ /pubmed/30115827 http://dx.doi.org/10.3390/nu10081098 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kohler, Lindsay N.
Harris, Robin B.
Oren, Eyal
Roe, Denise J.
Lance, Peter
Jacobs, Elizabeth T.
Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma
title Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma
title_full Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma
title_fullStr Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma
title_full_unstemmed Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma
title_short Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma
title_sort adherence to nutrition and physical activity cancer prevention guidelines and development of colorectal adenoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115749/
https://www.ncbi.nlm.nih.gov/pubmed/30115827
http://dx.doi.org/10.3390/nu10081098
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