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The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53
The tumor suppressor p53 is a transcriptional factor broadly mutated in cancer. Most inactivating and gain of function mutations disrupt the sequence-specific DNA binding domain, which activates target genes. This is perhaps the main reason why most research has focused on the relevance of such tran...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115784/ https://www.ncbi.nlm.nih.gov/pubmed/30060597 http://dx.doi.org/10.3390/cancers10080250 |