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Uric Acid and Cognitive Function in Older Individuals

Hyperuricemia has been recognized as an independent cardiovascular risk factor in epidemiological studies. However, uric acid can also exert beneficial functions due to its antioxidant properties, which may be particularly relevant in the context of neurodegenerative diseases. In this paper, we crit...

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Autores principales: Tana, Claudio, Ticinesi, Andrea, Prati, Beatrice, Nouvenne, Antonio, Meschi, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115794/
https://www.ncbi.nlm.nih.gov/pubmed/30060474
http://dx.doi.org/10.3390/nu10080975
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author Tana, Claudio
Ticinesi, Andrea
Prati, Beatrice
Nouvenne, Antonio
Meschi, Tiziana
author_facet Tana, Claudio
Ticinesi, Andrea
Prati, Beatrice
Nouvenne, Antonio
Meschi, Tiziana
author_sort Tana, Claudio
collection PubMed
description Hyperuricemia has been recognized as an independent cardiovascular risk factor in epidemiological studies. However, uric acid can also exert beneficial functions due to its antioxidant properties, which may be particularly relevant in the context of neurodegenerative diseases. In this paper, we critically revise the evidence on the relationship between serum uric acid levels and cognitive function in older individuals, focusing on the etiology of cognitive impairment (Alzheimer’s disease, Parkinson’s dementia, and vascular dementia) and on the interactive connections between uric acid, dementia, and diet. Despite high heterogeneity in the existing studies, due to different characteristics of studied populations and methods of cognitive dysfunction assessment, we conclude that serum uric acid may modulate cognitive function in a different way according to the etiology of dementia. Current studies indeed demonstrate that uric acid may exert neuroprotective actions in Alzheimer’s disease and Parkinson’s dementia, with hypouricemia representing a risk factor for a quicker disease progression and a possible marker of malnutrition. Conversely, high serum uric acid may negatively influence the disease course in vascular dementia. Further studies are needed to clarify the physio-pathological role of uric acid in different dementia types, and its clinical-prognostic significance.
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spelling pubmed-61157942018-09-04 Uric Acid and Cognitive Function in Older Individuals Tana, Claudio Ticinesi, Andrea Prati, Beatrice Nouvenne, Antonio Meschi, Tiziana Nutrients Review Hyperuricemia has been recognized as an independent cardiovascular risk factor in epidemiological studies. However, uric acid can also exert beneficial functions due to its antioxidant properties, which may be particularly relevant in the context of neurodegenerative diseases. In this paper, we critically revise the evidence on the relationship between serum uric acid levels and cognitive function in older individuals, focusing on the etiology of cognitive impairment (Alzheimer’s disease, Parkinson’s dementia, and vascular dementia) and on the interactive connections between uric acid, dementia, and diet. Despite high heterogeneity in the existing studies, due to different characteristics of studied populations and methods of cognitive dysfunction assessment, we conclude that serum uric acid may modulate cognitive function in a different way according to the etiology of dementia. Current studies indeed demonstrate that uric acid may exert neuroprotective actions in Alzheimer’s disease and Parkinson’s dementia, with hypouricemia representing a risk factor for a quicker disease progression and a possible marker of malnutrition. Conversely, high serum uric acid may negatively influence the disease course in vascular dementia. Further studies are needed to clarify the physio-pathological role of uric acid in different dementia types, and its clinical-prognostic significance. MDPI 2018-07-27 /pmc/articles/PMC6115794/ /pubmed/30060474 http://dx.doi.org/10.3390/nu10080975 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tana, Claudio
Ticinesi, Andrea
Prati, Beatrice
Nouvenne, Antonio
Meschi, Tiziana
Uric Acid and Cognitive Function in Older Individuals
title Uric Acid and Cognitive Function in Older Individuals
title_full Uric Acid and Cognitive Function in Older Individuals
title_fullStr Uric Acid and Cognitive Function in Older Individuals
title_full_unstemmed Uric Acid and Cognitive Function in Older Individuals
title_short Uric Acid and Cognitive Function in Older Individuals
title_sort uric acid and cognitive function in older individuals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115794/
https://www.ncbi.nlm.nih.gov/pubmed/30060474
http://dx.doi.org/10.3390/nu10080975
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