Cargando…

Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls

Objective: Diminished blood levels of zinc have been reported to be associated with T-cell-mediated autoimmunity, which has been implicated in multiple sclerosis (MS). We aimed to compare the distribution of serum zinc status in MS patients with that in healthy controls (HCs) and to investigate a po...

Descripción completa

Detalles Bibliográficos
Autores principales: Pawlitzki, Marc, Uebelhör, Julia, Sweeney-Reed, Catherine M., Stephanik, Heike, Hoffmann, Juliane, Lux, Anke, Reinhold, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115799/
https://www.ncbi.nlm.nih.gov/pubmed/30049983
http://dx.doi.org/10.3390/nu10080967
_version_ 1783351464358313984
author Pawlitzki, Marc
Uebelhör, Julia
Sweeney-Reed, Catherine M.
Stephanik, Heike
Hoffmann, Juliane
Lux, Anke
Reinhold, Dirk
author_facet Pawlitzki, Marc
Uebelhör, Julia
Sweeney-Reed, Catherine M.
Stephanik, Heike
Hoffmann, Juliane
Lux, Anke
Reinhold, Dirk
author_sort Pawlitzki, Marc
collection PubMed
description Objective: Diminished blood levels of zinc have been reported to be associated with T-cell-mediated autoimmunity, which has been implicated in multiple sclerosis (MS). We aimed to compare the distribution of serum zinc status in MS patients with that in healthy controls (HCs) and to investigate a potential correlation with clinical state, through analysis of serum zinc concentration in MS patients suffering from different disease subtypes. Methods: Serum zinc concentrations of 133 patients with relapsing (RMS) and 18 patients with the progressive form of MS (PMS), according to the McDonald criteria of 2010, were measured. Clinical status was quantified using the Expanded Disability Status Scale (EDSS). Zinc concentrations were also determined in the sera of 50 HCs, matched for age and sex at a group level. Results: MS patients showed significantly lower zinc concentrations (mean (SD)) than HCs (12.5 (2.1) µmol/L vs. 14.6 (2.3) µmol/L, p < 0.001). In contrast, we did not find any difference between RMS (12.4 (2.0) µmol/L) and PMS (13.0 (3.0) µmol/L) cases (p = 0.8). Patients receiving disease-modifying treatment showed lower mean (SD) serum zinc levels than untreated cases (12.3 (1.9) µmol/L vs. 13.5 (3.2) µmol/L, p < 0.03). Zinc levels were not related to disease duration, EDSS, annual relapse rate, or the median number of relapses. Conclusions: The data suggest that a diagnosis of MS is related to lower serum zinc concentrations than in HCs, and concentrations were lower still under disease-modifying therapy. However, zinc levels did not predict disease subtypes or disability status.
format Online
Article
Text
id pubmed-6115799
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61157992018-09-04 Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls Pawlitzki, Marc Uebelhör, Julia Sweeney-Reed, Catherine M. Stephanik, Heike Hoffmann, Juliane Lux, Anke Reinhold, Dirk Nutrients Article Objective: Diminished blood levels of zinc have been reported to be associated with T-cell-mediated autoimmunity, which has been implicated in multiple sclerosis (MS). We aimed to compare the distribution of serum zinc status in MS patients with that in healthy controls (HCs) and to investigate a potential correlation with clinical state, through analysis of serum zinc concentration in MS patients suffering from different disease subtypes. Methods: Serum zinc concentrations of 133 patients with relapsing (RMS) and 18 patients with the progressive form of MS (PMS), according to the McDonald criteria of 2010, were measured. Clinical status was quantified using the Expanded Disability Status Scale (EDSS). Zinc concentrations were also determined in the sera of 50 HCs, matched for age and sex at a group level. Results: MS patients showed significantly lower zinc concentrations (mean (SD)) than HCs (12.5 (2.1) µmol/L vs. 14.6 (2.3) µmol/L, p < 0.001). In contrast, we did not find any difference between RMS (12.4 (2.0) µmol/L) and PMS (13.0 (3.0) µmol/L) cases (p = 0.8). Patients receiving disease-modifying treatment showed lower mean (SD) serum zinc levels than untreated cases (12.3 (1.9) µmol/L vs. 13.5 (3.2) µmol/L, p < 0.03). Zinc levels were not related to disease duration, EDSS, annual relapse rate, or the median number of relapses. Conclusions: The data suggest that a diagnosis of MS is related to lower serum zinc concentrations than in HCs, and concentrations were lower still under disease-modifying therapy. However, zinc levels did not predict disease subtypes or disability status. MDPI 2018-07-26 /pmc/articles/PMC6115799/ /pubmed/30049983 http://dx.doi.org/10.3390/nu10080967 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pawlitzki, Marc
Uebelhör, Julia
Sweeney-Reed, Catherine M.
Stephanik, Heike
Hoffmann, Juliane
Lux, Anke
Reinhold, Dirk
Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls
title Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls
title_full Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls
title_fullStr Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls
title_full_unstemmed Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls
title_short Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls
title_sort lower serum zinc levels in patients with multiple sclerosis compared to healthy controls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115799/
https://www.ncbi.nlm.nih.gov/pubmed/30049983
http://dx.doi.org/10.3390/nu10080967
work_keys_str_mv AT pawlitzkimarc lowerserumzinclevelsinpatientswithmultiplesclerosiscomparedtohealthycontrols
AT uebelhorjulia lowerserumzinclevelsinpatientswithmultiplesclerosiscomparedtohealthycontrols
AT sweeneyreedcatherinem lowerserumzinclevelsinpatientswithmultiplesclerosiscomparedtohealthycontrols
AT stephanikheike lowerserumzinclevelsinpatientswithmultiplesclerosiscomparedtohealthycontrols
AT hoffmannjuliane lowerserumzinclevelsinpatientswithmultiplesclerosiscomparedtohealthycontrols
AT luxanke lowerserumzinclevelsinpatientswithmultiplesclerosiscomparedtohealthycontrols
AT reinholddirk lowerserumzinclevelsinpatientswithmultiplesclerosiscomparedtohealthycontrols