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Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls
Objective: Diminished blood levels of zinc have been reported to be associated with T-cell-mediated autoimmunity, which has been implicated in multiple sclerosis (MS). We aimed to compare the distribution of serum zinc status in MS patients with that in healthy controls (HCs) and to investigate a po...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115799/ https://www.ncbi.nlm.nih.gov/pubmed/30049983 http://dx.doi.org/10.3390/nu10080967 |
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author | Pawlitzki, Marc Uebelhör, Julia Sweeney-Reed, Catherine M. Stephanik, Heike Hoffmann, Juliane Lux, Anke Reinhold, Dirk |
author_facet | Pawlitzki, Marc Uebelhör, Julia Sweeney-Reed, Catherine M. Stephanik, Heike Hoffmann, Juliane Lux, Anke Reinhold, Dirk |
author_sort | Pawlitzki, Marc |
collection | PubMed |
description | Objective: Diminished blood levels of zinc have been reported to be associated with T-cell-mediated autoimmunity, which has been implicated in multiple sclerosis (MS). We aimed to compare the distribution of serum zinc status in MS patients with that in healthy controls (HCs) and to investigate a potential correlation with clinical state, through analysis of serum zinc concentration in MS patients suffering from different disease subtypes. Methods: Serum zinc concentrations of 133 patients with relapsing (RMS) and 18 patients with the progressive form of MS (PMS), according to the McDonald criteria of 2010, were measured. Clinical status was quantified using the Expanded Disability Status Scale (EDSS). Zinc concentrations were also determined in the sera of 50 HCs, matched for age and sex at a group level. Results: MS patients showed significantly lower zinc concentrations (mean (SD)) than HCs (12.5 (2.1) µmol/L vs. 14.6 (2.3) µmol/L, p < 0.001). In contrast, we did not find any difference between RMS (12.4 (2.0) µmol/L) and PMS (13.0 (3.0) µmol/L) cases (p = 0.8). Patients receiving disease-modifying treatment showed lower mean (SD) serum zinc levels than untreated cases (12.3 (1.9) µmol/L vs. 13.5 (3.2) µmol/L, p < 0.03). Zinc levels were not related to disease duration, EDSS, annual relapse rate, or the median number of relapses. Conclusions: The data suggest that a diagnosis of MS is related to lower serum zinc concentrations than in HCs, and concentrations were lower still under disease-modifying therapy. However, zinc levels did not predict disease subtypes or disability status. |
format | Online Article Text |
id | pubmed-6115799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61157992018-09-04 Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls Pawlitzki, Marc Uebelhör, Julia Sweeney-Reed, Catherine M. Stephanik, Heike Hoffmann, Juliane Lux, Anke Reinhold, Dirk Nutrients Article Objective: Diminished blood levels of zinc have been reported to be associated with T-cell-mediated autoimmunity, which has been implicated in multiple sclerosis (MS). We aimed to compare the distribution of serum zinc status in MS patients with that in healthy controls (HCs) and to investigate a potential correlation with clinical state, through analysis of serum zinc concentration in MS patients suffering from different disease subtypes. Methods: Serum zinc concentrations of 133 patients with relapsing (RMS) and 18 patients with the progressive form of MS (PMS), according to the McDonald criteria of 2010, were measured. Clinical status was quantified using the Expanded Disability Status Scale (EDSS). Zinc concentrations were also determined in the sera of 50 HCs, matched for age and sex at a group level. Results: MS patients showed significantly lower zinc concentrations (mean (SD)) than HCs (12.5 (2.1) µmol/L vs. 14.6 (2.3) µmol/L, p < 0.001). In contrast, we did not find any difference between RMS (12.4 (2.0) µmol/L) and PMS (13.0 (3.0) µmol/L) cases (p = 0.8). Patients receiving disease-modifying treatment showed lower mean (SD) serum zinc levels than untreated cases (12.3 (1.9) µmol/L vs. 13.5 (3.2) µmol/L, p < 0.03). Zinc levels were not related to disease duration, EDSS, annual relapse rate, or the median number of relapses. Conclusions: The data suggest that a diagnosis of MS is related to lower serum zinc concentrations than in HCs, and concentrations were lower still under disease-modifying therapy. However, zinc levels did not predict disease subtypes or disability status. MDPI 2018-07-26 /pmc/articles/PMC6115799/ /pubmed/30049983 http://dx.doi.org/10.3390/nu10080967 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pawlitzki, Marc Uebelhör, Julia Sweeney-Reed, Catherine M. Stephanik, Heike Hoffmann, Juliane Lux, Anke Reinhold, Dirk Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls |
title | Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls |
title_full | Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls |
title_fullStr | Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls |
title_full_unstemmed | Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls |
title_short | Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls |
title_sort | lower serum zinc levels in patients with multiple sclerosis compared to healthy controls |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115799/ https://www.ncbi.nlm.nih.gov/pubmed/30049983 http://dx.doi.org/10.3390/nu10080967 |
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