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Maternal and Paternal Caffeine Intake and ART Outcomes in Couples Referring to an Italian Fertility Clinic: A Prospective Cohort

Caffeine intake, a frequent lifestyle exposure, has a number of biological effects. We designed a cohort study to investigate the relation between lifestyle and assisted reproduction technique (ART) outcomes. From September 2014 to December 2016, 339 subfertile couples referring to an Italian fertil...

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Autores principales: Ricci, Elena, Noli, Stefania, Cipriani, Sonia, La Vecchia, Irene, Chiaffarino, Francesca, Ferrari, Stefania, Mauri, Paola Agnese, Reschini, Marco, Fedele, Luigi, Parazzini, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115800/
https://www.ncbi.nlm.nih.gov/pubmed/30126155
http://dx.doi.org/10.3390/nu10081116
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author Ricci, Elena
Noli, Stefania
Cipriani, Sonia
La Vecchia, Irene
Chiaffarino, Francesca
Ferrari, Stefania
Mauri, Paola Agnese
Reschini, Marco
Fedele, Luigi
Parazzini, Fabio
author_facet Ricci, Elena
Noli, Stefania
Cipriani, Sonia
La Vecchia, Irene
Chiaffarino, Francesca
Ferrari, Stefania
Mauri, Paola Agnese
Reschini, Marco
Fedele, Luigi
Parazzini, Fabio
author_sort Ricci, Elena
collection PubMed
description Caffeine intake, a frequent lifestyle exposure, has a number of biological effects. We designed a cohort study to investigate the relation between lifestyle and assisted reproduction technique (ART) outcomes. From September 2014 to December 2016, 339 subfertile couples referring to an Italian fertility clinic and eligible for ART procedures were enrolled in our study. Sociodemographic characteristics, smoking, and usual alcohol and caffeine consumption in the year prior to ART were recorded. The mean age of participants was 36.6 ± 3.6 years in women and 39.4 ± 5.2 years in men. After oocytes retrieval, 293 (86.4%) underwent implantation, 110 (32.4%) achieved clinical pregnancy, and 82 (24.2%) live birth. Maternal age was the main determinant of ART outcome. In a model including women’s age and college degree, smoking habits, calorie and alcohol intake for both partners, previous ART cycles, and partner’s caffeine intake, we did not observe any association between caffeine intake and ART outcome. Using the first tertile of caffeine intake by women as a reference, the adjusted rate ratio (ARR) for live birth was 1.09 (95% confidence interval (CI) 0.79–1.50) in the second and 0.99 (95% CI 0.71–1.40) in the third tertiles. In conclusion, a moderate caffeine intake by women and men in the year prior to the ART procedure was not associated with negative ART outcomes.
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spelling pubmed-61158002018-09-04 Maternal and Paternal Caffeine Intake and ART Outcomes in Couples Referring to an Italian Fertility Clinic: A Prospective Cohort Ricci, Elena Noli, Stefania Cipriani, Sonia La Vecchia, Irene Chiaffarino, Francesca Ferrari, Stefania Mauri, Paola Agnese Reschini, Marco Fedele, Luigi Parazzini, Fabio Nutrients Article Caffeine intake, a frequent lifestyle exposure, has a number of biological effects. We designed a cohort study to investigate the relation between lifestyle and assisted reproduction technique (ART) outcomes. From September 2014 to December 2016, 339 subfertile couples referring to an Italian fertility clinic and eligible for ART procedures were enrolled in our study. Sociodemographic characteristics, smoking, and usual alcohol and caffeine consumption in the year prior to ART were recorded. The mean age of participants was 36.6 ± 3.6 years in women and 39.4 ± 5.2 years in men. After oocytes retrieval, 293 (86.4%) underwent implantation, 110 (32.4%) achieved clinical pregnancy, and 82 (24.2%) live birth. Maternal age was the main determinant of ART outcome. In a model including women’s age and college degree, smoking habits, calorie and alcohol intake for both partners, previous ART cycles, and partner’s caffeine intake, we did not observe any association between caffeine intake and ART outcome. Using the first tertile of caffeine intake by women as a reference, the adjusted rate ratio (ARR) for live birth was 1.09 (95% confidence interval (CI) 0.79–1.50) in the second and 0.99 (95% CI 0.71–1.40) in the third tertiles. In conclusion, a moderate caffeine intake by women and men in the year prior to the ART procedure was not associated with negative ART outcomes. MDPI 2018-08-17 /pmc/articles/PMC6115800/ /pubmed/30126155 http://dx.doi.org/10.3390/nu10081116 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ricci, Elena
Noli, Stefania
Cipriani, Sonia
La Vecchia, Irene
Chiaffarino, Francesca
Ferrari, Stefania
Mauri, Paola Agnese
Reschini, Marco
Fedele, Luigi
Parazzini, Fabio
Maternal and Paternal Caffeine Intake and ART Outcomes in Couples Referring to an Italian Fertility Clinic: A Prospective Cohort
title Maternal and Paternal Caffeine Intake and ART Outcomes in Couples Referring to an Italian Fertility Clinic: A Prospective Cohort
title_full Maternal and Paternal Caffeine Intake and ART Outcomes in Couples Referring to an Italian Fertility Clinic: A Prospective Cohort
title_fullStr Maternal and Paternal Caffeine Intake and ART Outcomes in Couples Referring to an Italian Fertility Clinic: A Prospective Cohort
title_full_unstemmed Maternal and Paternal Caffeine Intake and ART Outcomes in Couples Referring to an Italian Fertility Clinic: A Prospective Cohort
title_short Maternal and Paternal Caffeine Intake and ART Outcomes in Couples Referring to an Italian Fertility Clinic: A Prospective Cohort
title_sort maternal and paternal caffeine intake and art outcomes in couples referring to an italian fertility clinic: a prospective cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115800/
https://www.ncbi.nlm.nih.gov/pubmed/30126155
http://dx.doi.org/10.3390/nu10081116
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