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Real-World Implications of Nonbiological Factors with Staging, Prognosis and Clinical Management in Colon Cancer
Background: The present study analyzed the nonbiological factors (NBFs) together with the American Joint Committee on Cancer (AJCC) Tumor-Node-Metastasis (TNM) staging system to generate a refined, risk-adapted stage for the clinical treatment of colon cancer. Methods: Eligible patients (N = 28,818)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115817/ https://www.ncbi.nlm.nih.gov/pubmed/30096811 http://dx.doi.org/10.3390/cancers10080263 |
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author | Liu, Qi Luo, Dakui Cai, Sanjun Li, Qingguo Li, Xinxiang |
author_facet | Liu, Qi Luo, Dakui Cai, Sanjun Li, Qingguo Li, Xinxiang |
author_sort | Liu, Qi |
collection | PubMed |
description | Background: The present study analyzed the nonbiological factors (NBFs) together with the American Joint Committee on Cancer (AJCC) Tumor-Node-Metastasis (TNM) staging system to generate a refined, risk-adapted stage for the clinical treatment of colon cancer. Methods: Eligible patients (N = 28,818) with colon cancer between 1 January 2010 and 31 December 2014, were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier curves and Cox proportional hazards regression, analyzed the probabilities of cancer-specific survival (CSS) in patients with colon cancer, with different NBF-TNM stages. Results: Insurance status, marital status, and median household income were significant prognostic NBFs in the current study (p < 0.05). The concordance index of NBF-TNM stage was 0.857 (95% confidence interval (CI) = 0.8472–0.8668). Multivariate Cox analyses, indicated that NBF1-stage was independently associated with a 50.4% increased risk of cancer-specific mortality in colon cancer (p < 0.001), which increased to 77.1% in non-metastatic colon cancer. NBF0-stage improved in CSS as compared to the NBF1-stage in the respective stages (p < 0.05). Conclusions: The new proposed NBF-stage was an independent prognostic factor in colon cancer. Effect of NBFs on the survival of colon cancer necessitates further clinical attention. Moreover, the incorporation of NBF-stage into the AJCC TNM staging system is essential for prognostic prediction, and clinical guidance of adjuvant chemotherapy in stage II and III colon cancer. |
format | Online Article Text |
id | pubmed-6115817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61158172018-08-31 Real-World Implications of Nonbiological Factors with Staging, Prognosis and Clinical Management in Colon Cancer Liu, Qi Luo, Dakui Cai, Sanjun Li, Qingguo Li, Xinxiang Cancers (Basel) Article Background: The present study analyzed the nonbiological factors (NBFs) together with the American Joint Committee on Cancer (AJCC) Tumor-Node-Metastasis (TNM) staging system to generate a refined, risk-adapted stage for the clinical treatment of colon cancer. Methods: Eligible patients (N = 28,818) with colon cancer between 1 January 2010 and 31 December 2014, were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier curves and Cox proportional hazards regression, analyzed the probabilities of cancer-specific survival (CSS) in patients with colon cancer, with different NBF-TNM stages. Results: Insurance status, marital status, and median household income were significant prognostic NBFs in the current study (p < 0.05). The concordance index of NBF-TNM stage was 0.857 (95% confidence interval (CI) = 0.8472–0.8668). Multivariate Cox analyses, indicated that NBF1-stage was independently associated with a 50.4% increased risk of cancer-specific mortality in colon cancer (p < 0.001), which increased to 77.1% in non-metastatic colon cancer. NBF0-stage improved in CSS as compared to the NBF1-stage in the respective stages (p < 0.05). Conclusions: The new proposed NBF-stage was an independent prognostic factor in colon cancer. Effect of NBFs on the survival of colon cancer necessitates further clinical attention. Moreover, the incorporation of NBF-stage into the AJCC TNM staging system is essential for prognostic prediction, and clinical guidance of adjuvant chemotherapy in stage II and III colon cancer. MDPI 2018-08-08 /pmc/articles/PMC6115817/ /pubmed/30096811 http://dx.doi.org/10.3390/cancers10080263 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Qi Luo, Dakui Cai, Sanjun Li, Qingguo Li, Xinxiang Real-World Implications of Nonbiological Factors with Staging, Prognosis and Clinical Management in Colon Cancer |
title | Real-World Implications of Nonbiological Factors with Staging, Prognosis and Clinical Management in Colon Cancer |
title_full | Real-World Implications of Nonbiological Factors with Staging, Prognosis and Clinical Management in Colon Cancer |
title_fullStr | Real-World Implications of Nonbiological Factors with Staging, Prognosis and Clinical Management in Colon Cancer |
title_full_unstemmed | Real-World Implications of Nonbiological Factors with Staging, Prognosis and Clinical Management in Colon Cancer |
title_short | Real-World Implications of Nonbiological Factors with Staging, Prognosis and Clinical Management in Colon Cancer |
title_sort | real-world implications of nonbiological factors with staging, prognosis and clinical management in colon cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115817/ https://www.ncbi.nlm.nih.gov/pubmed/30096811 http://dx.doi.org/10.3390/cancers10080263 |
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