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Mediterranean Diet and Bladder Cancer Risk in Italy

Previous studies have reported that Mediterranean diet is inversely related to the risk of several neoplasms; however, limited epidemiological data are available for bladder cancer. Thus, we examined the association between Mediterranean diet and this neoplasm in an Italian multicentric case-control...

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Autores principales: Bravi, Francesca, Spei, Maria-Eleni, Polesel, Jerry, Di Maso, Matteo, Montella, Maurizio, Ferraroni, Monica, Serraino, Diego, Libra, Massimo, Negri, Eva, La Vecchia, Carlo, Turati, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115823/
https://www.ncbi.nlm.nih.gov/pubmed/30103393
http://dx.doi.org/10.3390/nu10081061
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author Bravi, Francesca
Spei, Maria-Eleni
Polesel, Jerry
Di Maso, Matteo
Montella, Maurizio
Ferraroni, Monica
Serraino, Diego
Libra, Massimo
Negri, Eva
La Vecchia, Carlo
Turati, Federica
author_facet Bravi, Francesca
Spei, Maria-Eleni
Polesel, Jerry
Di Maso, Matteo
Montella, Maurizio
Ferraroni, Monica
Serraino, Diego
Libra, Massimo
Negri, Eva
La Vecchia, Carlo
Turati, Federica
author_sort Bravi, Francesca
collection PubMed
description Previous studies have reported that Mediterranean diet is inversely related to the risk of several neoplasms; however, limited epidemiological data are available for bladder cancer. Thus, we examined the association between Mediterranean diet and this neoplasm in an Italian multicentric case-control study consisting of 690 bladder cancer cases and 665 controls. We assessed the adherence to the Mediterranean diet via a Mediterranean Diet Score (MDS), which represents the major characteristics of the Mediterranean diet and ranges from 0 to 9 (from minimal to maximal adherence, respectively). We derived odds ratios (ORs) of bladder cancer according to the MDS score from multiple logistic regression models, allowing for major confounding factors. The ORs of bladder cancer were 0.72 (95% confidence interval, CI, 0.54–0.98) for MDS of 4–5 and 0.66 (95% CI, 0.47–0.93) for MDS of 6–9 (p for trend = 0.02) compared to MDS = 0–3. Results were similar in strata of sex, age, and education, while the risk appeared somewhat lower in never-smokers and patients with pT1–pT4 bladder carcinomas. Among individual components of the MDS, we observed inverse associations for greater consumption of legumes, vegetables, and fish. In our study, which was carried out on an Italian population, the higher adherence to the Mediterranean diet was related to a lower risk of bladder cancer.
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spelling pubmed-61158232018-09-04 Mediterranean Diet and Bladder Cancer Risk in Italy Bravi, Francesca Spei, Maria-Eleni Polesel, Jerry Di Maso, Matteo Montella, Maurizio Ferraroni, Monica Serraino, Diego Libra, Massimo Negri, Eva La Vecchia, Carlo Turati, Federica Nutrients Article Previous studies have reported that Mediterranean diet is inversely related to the risk of several neoplasms; however, limited epidemiological data are available for bladder cancer. Thus, we examined the association between Mediterranean diet and this neoplasm in an Italian multicentric case-control study consisting of 690 bladder cancer cases and 665 controls. We assessed the adherence to the Mediterranean diet via a Mediterranean Diet Score (MDS), which represents the major characteristics of the Mediterranean diet and ranges from 0 to 9 (from minimal to maximal adherence, respectively). We derived odds ratios (ORs) of bladder cancer according to the MDS score from multiple logistic regression models, allowing for major confounding factors. The ORs of bladder cancer were 0.72 (95% confidence interval, CI, 0.54–0.98) for MDS of 4–5 and 0.66 (95% CI, 0.47–0.93) for MDS of 6–9 (p for trend = 0.02) compared to MDS = 0–3. Results were similar in strata of sex, age, and education, while the risk appeared somewhat lower in never-smokers and patients with pT1–pT4 bladder carcinomas. Among individual components of the MDS, we observed inverse associations for greater consumption of legumes, vegetables, and fish. In our study, which was carried out on an Italian population, the higher adherence to the Mediterranean diet was related to a lower risk of bladder cancer. MDPI 2018-08-10 /pmc/articles/PMC6115823/ /pubmed/30103393 http://dx.doi.org/10.3390/nu10081061 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bravi, Francesca
Spei, Maria-Eleni
Polesel, Jerry
Di Maso, Matteo
Montella, Maurizio
Ferraroni, Monica
Serraino, Diego
Libra, Massimo
Negri, Eva
La Vecchia, Carlo
Turati, Federica
Mediterranean Diet and Bladder Cancer Risk in Italy
title Mediterranean Diet and Bladder Cancer Risk in Italy
title_full Mediterranean Diet and Bladder Cancer Risk in Italy
title_fullStr Mediterranean Diet and Bladder Cancer Risk in Italy
title_full_unstemmed Mediterranean Diet and Bladder Cancer Risk in Italy
title_short Mediterranean Diet and Bladder Cancer Risk in Italy
title_sort mediterranean diet and bladder cancer risk in italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115823/
https://www.ncbi.nlm.nih.gov/pubmed/30103393
http://dx.doi.org/10.3390/nu10081061
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