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Effects of Caffeine on Myocardial Blood Flow: A Systematic Review
Background. Caffeine is one of the most widely consumed stimulants worldwide. It is a well-recognized antagonist of adenosine and a potential cause of false-negative functional measurements during vasodilator myocardial perfusion. The aim of this systematic review is to summarize the evidence regard...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115837/ https://www.ncbi.nlm.nih.gov/pubmed/30104545 http://dx.doi.org/10.3390/nu10081083 |
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author | van Dijk, Randy Ties, Daan Kuijpers, Dirkjan van der Harst, Pim Oudkerk, Matthijs |
author_facet | van Dijk, Randy Ties, Daan Kuijpers, Dirkjan van der Harst, Pim Oudkerk, Matthijs |
author_sort | van Dijk, Randy |
collection | PubMed |
description | Background. Caffeine is one of the most widely consumed stimulants worldwide. It is a well-recognized antagonist of adenosine and a potential cause of false-negative functional measurements during vasodilator myocardial perfusion. The aim of this systematic review is to summarize the evidence regarding the effects of caffeine intake on functional measurements of myocardial perfusion in patients with suspected coronary artery disease. Pubmed, Web of Science, and Embase were searched using a predefined electronic search strategy. Participants—healthy subjects or patients with known or suspected CAD. Comparisons—recent caffeine intake versus no caffeine intake. Outcomes—measurements of functional myocardial perfusion. Study design—observational. Fourteen studies were deemed eligible for this systematic review. There was a wide range of variability in study design with varying imaging modalities, vasodilator agents, serum concentrations of caffeine, and primary outcome measurements. The available data indicate a significant influence of recent caffeine intake on cardiac perfusion measurements during adenosine and dipyridamole induced hyperemia. These effects have the potential to affect the clinical decision making by re-classification to different risk-categories. |
format | Online Article Text |
id | pubmed-6115837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61158372018-09-04 Effects of Caffeine on Myocardial Blood Flow: A Systematic Review van Dijk, Randy Ties, Daan Kuijpers, Dirkjan van der Harst, Pim Oudkerk, Matthijs Nutrients Review Background. Caffeine is one of the most widely consumed stimulants worldwide. It is a well-recognized antagonist of adenosine and a potential cause of false-negative functional measurements during vasodilator myocardial perfusion. The aim of this systematic review is to summarize the evidence regarding the effects of caffeine intake on functional measurements of myocardial perfusion in patients with suspected coronary artery disease. Pubmed, Web of Science, and Embase were searched using a predefined electronic search strategy. Participants—healthy subjects or patients with known or suspected CAD. Comparisons—recent caffeine intake versus no caffeine intake. Outcomes—measurements of functional myocardial perfusion. Study design—observational. Fourteen studies were deemed eligible for this systematic review. There was a wide range of variability in study design with varying imaging modalities, vasodilator agents, serum concentrations of caffeine, and primary outcome measurements. The available data indicate a significant influence of recent caffeine intake on cardiac perfusion measurements during adenosine and dipyridamole induced hyperemia. These effects have the potential to affect the clinical decision making by re-classification to different risk-categories. MDPI 2018-08-13 /pmc/articles/PMC6115837/ /pubmed/30104545 http://dx.doi.org/10.3390/nu10081083 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review van Dijk, Randy Ties, Daan Kuijpers, Dirkjan van der Harst, Pim Oudkerk, Matthijs Effects of Caffeine on Myocardial Blood Flow: A Systematic Review |
title | Effects of Caffeine on Myocardial Blood Flow: A Systematic Review |
title_full | Effects of Caffeine on Myocardial Blood Flow: A Systematic Review |
title_fullStr | Effects of Caffeine on Myocardial Blood Flow: A Systematic Review |
title_full_unstemmed | Effects of Caffeine on Myocardial Blood Flow: A Systematic Review |
title_short | Effects of Caffeine on Myocardial Blood Flow: A Systematic Review |
title_sort | effects of caffeine on myocardial blood flow: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115837/ https://www.ncbi.nlm.nih.gov/pubmed/30104545 http://dx.doi.org/10.3390/nu10081083 |
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