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Effects of Caffeine on Myocardial Blood Flow: A Systematic Review

Background. Caffeine is one of the most widely consumed stimulants worldwide. It is a well-recognized antagonist of adenosine and a potential cause of false-negative functional measurements during vasodilator myocardial perfusion. The aim of this systematic review is to summarize the evidence regard...

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Autores principales: van Dijk, Randy, Ties, Daan, Kuijpers, Dirkjan, van der Harst, Pim, Oudkerk, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115837/
https://www.ncbi.nlm.nih.gov/pubmed/30104545
http://dx.doi.org/10.3390/nu10081083
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author van Dijk, Randy
Ties, Daan
Kuijpers, Dirkjan
van der Harst, Pim
Oudkerk, Matthijs
author_facet van Dijk, Randy
Ties, Daan
Kuijpers, Dirkjan
van der Harst, Pim
Oudkerk, Matthijs
author_sort van Dijk, Randy
collection PubMed
description Background. Caffeine is one of the most widely consumed stimulants worldwide. It is a well-recognized antagonist of adenosine and a potential cause of false-negative functional measurements during vasodilator myocardial perfusion. The aim of this systematic review is to summarize the evidence regarding the effects of caffeine intake on functional measurements of myocardial perfusion in patients with suspected coronary artery disease. Pubmed, Web of Science, and Embase were searched using a predefined electronic search strategy. Participants—healthy subjects or patients with known or suspected CAD. Comparisons—recent caffeine intake versus no caffeine intake. Outcomes—measurements of functional myocardial perfusion. Study design—observational. Fourteen studies were deemed eligible for this systematic review. There was a wide range of variability in study design with varying imaging modalities, vasodilator agents, serum concentrations of caffeine, and primary outcome measurements. The available data indicate a significant influence of recent caffeine intake on cardiac perfusion measurements during adenosine and dipyridamole induced hyperemia. These effects have the potential to affect the clinical decision making by re-classification to different risk-categories.
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spelling pubmed-61158372018-09-04 Effects of Caffeine on Myocardial Blood Flow: A Systematic Review van Dijk, Randy Ties, Daan Kuijpers, Dirkjan van der Harst, Pim Oudkerk, Matthijs Nutrients Review Background. Caffeine is one of the most widely consumed stimulants worldwide. It is a well-recognized antagonist of adenosine and a potential cause of false-negative functional measurements during vasodilator myocardial perfusion. The aim of this systematic review is to summarize the evidence regarding the effects of caffeine intake on functional measurements of myocardial perfusion in patients with suspected coronary artery disease. Pubmed, Web of Science, and Embase were searched using a predefined electronic search strategy. Participants—healthy subjects or patients with known or suspected CAD. Comparisons—recent caffeine intake versus no caffeine intake. Outcomes—measurements of functional myocardial perfusion. Study design—observational. Fourteen studies were deemed eligible for this systematic review. There was a wide range of variability in study design with varying imaging modalities, vasodilator agents, serum concentrations of caffeine, and primary outcome measurements. The available data indicate a significant influence of recent caffeine intake on cardiac perfusion measurements during adenosine and dipyridamole induced hyperemia. These effects have the potential to affect the clinical decision making by re-classification to different risk-categories. MDPI 2018-08-13 /pmc/articles/PMC6115837/ /pubmed/30104545 http://dx.doi.org/10.3390/nu10081083 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
van Dijk, Randy
Ties, Daan
Kuijpers, Dirkjan
van der Harst, Pim
Oudkerk, Matthijs
Effects of Caffeine on Myocardial Blood Flow: A Systematic Review
title Effects of Caffeine on Myocardial Blood Flow: A Systematic Review
title_full Effects of Caffeine on Myocardial Blood Flow: A Systematic Review
title_fullStr Effects of Caffeine on Myocardial Blood Flow: A Systematic Review
title_full_unstemmed Effects of Caffeine on Myocardial Blood Flow: A Systematic Review
title_short Effects of Caffeine on Myocardial Blood Flow: A Systematic Review
title_sort effects of caffeine on myocardial blood flow: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115837/
https://www.ncbi.nlm.nih.gov/pubmed/30104545
http://dx.doi.org/10.3390/nu10081083
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