Using the Mutation-Selection Framework to Characterize Selection on Protein Sequences

When mutational pressure is weak, the generative process of protein evolution involves explicit probabilities of mutations of different types coupled to their conditional probabilities of fixation dependent on selection. Establishing this mechanistic modeling framework for the detection of selection...

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Detalles Bibliográficos
Autores principales: Teufel, Ashley I., Ritchie, Andrew M., Wilke, Claus O., Liberles, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115872/
https://www.ncbi.nlm.nih.gov/pubmed/30104502
http://dx.doi.org/10.3390/genes9080409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115872/
https://www.ncbi.nlm.nih.gov/pubmed/30104502
http://dx.doi.org/10.3390/genes9080409

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