Cargando…

Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure

Approximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a contributing cause. Current HF drugs (e.g., β-blockers, ACEi) target intracellular signaling cascades downstream of cell surface receptors to prevent ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Evans, Levi W., Ferguson, Bradley S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115944/
https://www.ncbi.nlm.nih.gov/pubmed/30126190
http://dx.doi.org/10.3390/nu10081120
_version_ 1783351497540501504
author Evans, Levi W.
Ferguson, Bradley S.
author_facet Evans, Levi W.
Ferguson, Bradley S.
author_sort Evans, Levi W.
collection PubMed
description Approximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a contributing cause. Current HF drugs (e.g., β-blockers, ACEi) target intracellular signaling cascades downstream of cell surface receptors to prevent cardiac pump dysfunction. However, these drugs fail to target other redundant intracellular signaling pathways and, therefore, limit drug efficacy. As such, it has been postulated that compounds designed to target shared downstream mediators of these signaling pathways would be more efficacious for the treatment of HF. Histone deacetylation has been linked as a key pathogenetic element for the development of HF. Lysine residues undergo diverse and reversible post-translational modifications that include acetylation and have historically been studied as epigenetic modifiers of histone tails within chromatin that provide an important mechanism for regulating gene expression. Of recent, bioactive compounds within our diet have been linked to the regulation of gene expression, in part, through regulation of the epi-genome. It has been reported that food bioactives regulate histone acetylation via direct regulation of writer (histone acetyl transferases, HATs) and eraser (histone deacetylases, HDACs) proteins. Therefore, bioactive food compounds offer unique therapeutic strategies as epigenetic modifiers of heart failure. This review will highlight food bio-actives as modifiers of histone deacetylase activity in the heart.
format Online
Article
Text
id pubmed-6115944
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61159442018-09-04 Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure Evans, Levi W. Ferguson, Bradley S. Nutrients Review Approximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a contributing cause. Current HF drugs (e.g., β-blockers, ACEi) target intracellular signaling cascades downstream of cell surface receptors to prevent cardiac pump dysfunction. However, these drugs fail to target other redundant intracellular signaling pathways and, therefore, limit drug efficacy. As such, it has been postulated that compounds designed to target shared downstream mediators of these signaling pathways would be more efficacious for the treatment of HF. Histone deacetylation has been linked as a key pathogenetic element for the development of HF. Lysine residues undergo diverse and reversible post-translational modifications that include acetylation and have historically been studied as epigenetic modifiers of histone tails within chromatin that provide an important mechanism for regulating gene expression. Of recent, bioactive compounds within our diet have been linked to the regulation of gene expression, in part, through regulation of the epi-genome. It has been reported that food bioactives regulate histone acetylation via direct regulation of writer (histone acetyl transferases, HATs) and eraser (histone deacetylases, HDACs) proteins. Therefore, bioactive food compounds offer unique therapeutic strategies as epigenetic modifiers of heart failure. This review will highlight food bio-actives as modifiers of histone deacetylase activity in the heart. MDPI 2018-08-18 /pmc/articles/PMC6115944/ /pubmed/30126190 http://dx.doi.org/10.3390/nu10081120 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Evans, Levi W.
Ferguson, Bradley S.
Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure
title Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure
title_full Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure
title_fullStr Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure
title_full_unstemmed Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure
title_short Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure
title_sort food bioactive hdac inhibitors in the epigenetic regulation of heart failure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115944/
https://www.ncbi.nlm.nih.gov/pubmed/30126190
http://dx.doi.org/10.3390/nu10081120
work_keys_str_mv AT evansleviw foodbioactivehdacinhibitorsintheepigeneticregulationofheartfailure
AT fergusonbradleys foodbioactivehdacinhibitorsintheepigeneticregulationofheartfailure