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Design, Development and Construct Validation of the Children’s Dietary Inflammatory Index

Objective: To design and validate a literature-derived, population-based Children’s Dietary Inflammatory Index (C-DII)(TM). Design: The C-DII was developed based on a review of literature through 2010. Dietary data obtained from children in 16 different countries were used to create a reference data...

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Detalles Bibliográficos
Autores principales: Khan, Samira, Wirth, Michael D., Ortaglia, Andrew, Alvarado, Christian R., Shivappa, Nitin, Hurley, Thomas G., Hebert, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115957/
https://www.ncbi.nlm.nih.gov/pubmed/30061487
http://dx.doi.org/10.3390/nu10080993
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author Khan, Samira
Wirth, Michael D.
Ortaglia, Andrew
Alvarado, Christian R.
Shivappa, Nitin
Hurley, Thomas G.
Hebert, James R.
author_facet Khan, Samira
Wirth, Michael D.
Ortaglia, Andrew
Alvarado, Christian R.
Shivappa, Nitin
Hurley, Thomas G.
Hebert, James R.
author_sort Khan, Samira
collection PubMed
description Objective: To design and validate a literature-derived, population-based Children’s Dietary Inflammatory Index (C-DII)(TM). Design: The C-DII was developed based on a review of literature through 2010. Dietary data obtained from children in 16 different countries were used to create a reference database for computing C-DII scores based on consumption of macronutrients, vitamins, minerals, and whole foods. Construct validation was performed using quantile regression to assess the association between C-reactive protein (CRP) concentrations and C-DII scores. Data Sources: All data used for construct validation were obtained from children between six and 14 years of age (n = 3300) who participated in the U.S. National Health and Nutrition Examination Survey (NHANES) (2005–2010). Results: The C-DII was successfully validated with blood CRP concentrations in this heterogeneous sample of 3300 children from NHANES (52% male; 29% African American, 25% Mexican American; mean age 11 years). The final model was adjusted for sex, age, race, asthma, body mass index (BMI), and infections. Children in level 3 (i.e., quartiles 3 and 4 combined) of the C-DII (i.e., children with the most pro-inflammatory diets) had a CRP value 0.097 mg/dL higher than that in level 1 (i.e., quartile 1) for CRP values at the 75th percentile of CRP using quantile regression (p < 0.05). Conclusion: The C-DII predicted blood CRP concentrations among children 6–14 years in the NHANES. Further construct validation with CRP and other inflammatory markers is required to deepen understanding of the relationship between the C-DII and markers of inflammation in children.
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spelling pubmed-61159572018-09-04 Design, Development and Construct Validation of the Children’s Dietary Inflammatory Index Khan, Samira Wirth, Michael D. Ortaglia, Andrew Alvarado, Christian R. Shivappa, Nitin Hurley, Thomas G. Hebert, James R. Nutrients Review Objective: To design and validate a literature-derived, population-based Children’s Dietary Inflammatory Index (C-DII)(TM). Design: The C-DII was developed based on a review of literature through 2010. Dietary data obtained from children in 16 different countries were used to create a reference database for computing C-DII scores based on consumption of macronutrients, vitamins, minerals, and whole foods. Construct validation was performed using quantile regression to assess the association between C-reactive protein (CRP) concentrations and C-DII scores. Data Sources: All data used for construct validation were obtained from children between six and 14 years of age (n = 3300) who participated in the U.S. National Health and Nutrition Examination Survey (NHANES) (2005–2010). Results: The C-DII was successfully validated with blood CRP concentrations in this heterogeneous sample of 3300 children from NHANES (52% male; 29% African American, 25% Mexican American; mean age 11 years). The final model was adjusted for sex, age, race, asthma, body mass index (BMI), and infections. Children in level 3 (i.e., quartiles 3 and 4 combined) of the C-DII (i.e., children with the most pro-inflammatory diets) had a CRP value 0.097 mg/dL higher than that in level 1 (i.e., quartile 1) for CRP values at the 75th percentile of CRP using quantile regression (p < 0.05). Conclusion: The C-DII predicted blood CRP concentrations among children 6–14 years in the NHANES. Further construct validation with CRP and other inflammatory markers is required to deepen understanding of the relationship between the C-DII and markers of inflammation in children. MDPI 2018-07-30 /pmc/articles/PMC6115957/ /pubmed/30061487 http://dx.doi.org/10.3390/nu10080993 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khan, Samira
Wirth, Michael D.
Ortaglia, Andrew
Alvarado, Christian R.
Shivappa, Nitin
Hurley, Thomas G.
Hebert, James R.
Design, Development and Construct Validation of the Children’s Dietary Inflammatory Index
title Design, Development and Construct Validation of the Children’s Dietary Inflammatory Index
title_full Design, Development and Construct Validation of the Children’s Dietary Inflammatory Index
title_fullStr Design, Development and Construct Validation of the Children’s Dietary Inflammatory Index
title_full_unstemmed Design, Development and Construct Validation of the Children’s Dietary Inflammatory Index
title_short Design, Development and Construct Validation of the Children’s Dietary Inflammatory Index
title_sort design, development and construct validation of the children’s dietary inflammatory index
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115957/
https://www.ncbi.nlm.nih.gov/pubmed/30061487
http://dx.doi.org/10.3390/nu10080993
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