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Radiotherapy for T1N0M0 Esophageal Cancer: Analyses of the Predictive Factors and the Role of Endoscopic Submucosal Dissection in the Local Control

Several therapeutic options are available for clinical T1N0M0 thoracic esophageal squamous cell carcinoma (stage I ESCC); however, the studies on the treatment results are limited. This study assessed the outcomes of stage I ESCC treated with radiotherapy (RT), determined predictive factors, and eva...

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Autores principales: Suzuki, Gen, Yamazaki, Hideya, Aibe, Norihiro, Masui, Koji, Shimizu, Daisuke, Kimoto, Takuya, Nishimura, Takeshi, Nakashima, Akihiro, Takenaka, Tadashi, Dohi, Osamu, Ishikawa, Takeshi, Yamada, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115973/
https://www.ncbi.nlm.nih.gov/pubmed/30081489
http://dx.doi.org/10.3390/cancers10080259
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author Suzuki, Gen
Yamazaki, Hideya
Aibe, Norihiro
Masui, Koji
Shimizu, Daisuke
Kimoto, Takuya
Nishimura, Takeshi
Nakashima, Akihiro
Takenaka, Tadashi
Dohi, Osamu
Ishikawa, Takeshi
Yamada, Kei
author_facet Suzuki, Gen
Yamazaki, Hideya
Aibe, Norihiro
Masui, Koji
Shimizu, Daisuke
Kimoto, Takuya
Nishimura, Takeshi
Nakashima, Akihiro
Takenaka, Tadashi
Dohi, Osamu
Ishikawa, Takeshi
Yamada, Kei
author_sort Suzuki, Gen
collection PubMed
description Several therapeutic options are available for clinical T1N0M0 thoracic esophageal squamous cell carcinoma (stage I ESCC); however, the studies on the treatment results are limited. This study assessed the outcomes of stage I ESCC treated with radiotherapy (RT), determined predictive factors, and evaluated the benefits of endoscopic submucosal dissection (ESD) combined with RT. We retrospectively analyzed the data of 50 patients (41 men, 9 women; median age, 66 years) with stage I ESCC treated with RT. The median total irradiation dose was 50 Gy. Elective nodal irradiation (ENI) was performed in 17 patients and ESD in 29 patients (ESD group). Forty-six patients concurrently received chemotherapy with RT. The median tumor length of ESD and non-ESD groups was 2.3 and 5 cm, respectively. The median follow-up was 33 months. The 3-year overall survival, disease-free survival (DFS), and local control (LC) rates were 77.3%, 61.1%, and 88.1%, respectively. Grade 3 adverse events occurred in 14 patients. T stage and tumor length were significant prognostic factors for 3-year DFS and 3-year LC, respectively. ESD appeared to be an important prognostic factor for LC. ENI and total irradiation dose above 50.4 Gy were not predictive factors. Our findings might help in treatment decisions for stage I ESCC.
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spelling pubmed-61159732018-08-31 Radiotherapy for T1N0M0 Esophageal Cancer: Analyses of the Predictive Factors and the Role of Endoscopic Submucosal Dissection in the Local Control Suzuki, Gen Yamazaki, Hideya Aibe, Norihiro Masui, Koji Shimizu, Daisuke Kimoto, Takuya Nishimura, Takeshi Nakashima, Akihiro Takenaka, Tadashi Dohi, Osamu Ishikawa, Takeshi Yamada, Kei Cancers (Basel) Article Several therapeutic options are available for clinical T1N0M0 thoracic esophageal squamous cell carcinoma (stage I ESCC); however, the studies on the treatment results are limited. This study assessed the outcomes of stage I ESCC treated with radiotherapy (RT), determined predictive factors, and evaluated the benefits of endoscopic submucosal dissection (ESD) combined with RT. We retrospectively analyzed the data of 50 patients (41 men, 9 women; median age, 66 years) with stage I ESCC treated with RT. The median total irradiation dose was 50 Gy. Elective nodal irradiation (ENI) was performed in 17 patients and ESD in 29 patients (ESD group). Forty-six patients concurrently received chemotherapy with RT. The median tumor length of ESD and non-ESD groups was 2.3 and 5 cm, respectively. The median follow-up was 33 months. The 3-year overall survival, disease-free survival (DFS), and local control (LC) rates were 77.3%, 61.1%, and 88.1%, respectively. Grade 3 adverse events occurred in 14 patients. T stage and tumor length were significant prognostic factors for 3-year DFS and 3-year LC, respectively. ESD appeared to be an important prognostic factor for LC. ENI and total irradiation dose above 50.4 Gy were not predictive factors. Our findings might help in treatment decisions for stage I ESCC. MDPI 2018-08-03 /pmc/articles/PMC6115973/ /pubmed/30081489 http://dx.doi.org/10.3390/cancers10080259 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suzuki, Gen
Yamazaki, Hideya
Aibe, Norihiro
Masui, Koji
Shimizu, Daisuke
Kimoto, Takuya
Nishimura, Takeshi
Nakashima, Akihiro
Takenaka, Tadashi
Dohi, Osamu
Ishikawa, Takeshi
Yamada, Kei
Radiotherapy for T1N0M0 Esophageal Cancer: Analyses of the Predictive Factors and the Role of Endoscopic Submucosal Dissection in the Local Control
title Radiotherapy for T1N0M0 Esophageal Cancer: Analyses of the Predictive Factors and the Role of Endoscopic Submucosal Dissection in the Local Control
title_full Radiotherapy for T1N0M0 Esophageal Cancer: Analyses of the Predictive Factors and the Role of Endoscopic Submucosal Dissection in the Local Control
title_fullStr Radiotherapy for T1N0M0 Esophageal Cancer: Analyses of the Predictive Factors and the Role of Endoscopic Submucosal Dissection in the Local Control
title_full_unstemmed Radiotherapy for T1N0M0 Esophageal Cancer: Analyses of the Predictive Factors and the Role of Endoscopic Submucosal Dissection in the Local Control
title_short Radiotherapy for T1N0M0 Esophageal Cancer: Analyses of the Predictive Factors and the Role of Endoscopic Submucosal Dissection in the Local Control
title_sort radiotherapy for t1n0m0 esophageal cancer: analyses of the predictive factors and the role of endoscopic submucosal dissection in the local control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115973/
https://www.ncbi.nlm.nih.gov/pubmed/30081489
http://dx.doi.org/10.3390/cancers10080259
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