The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly c...

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Autores principales: Velapasamy, Sharmila, Dawson, Christopher W., Young, Lawrence S., Paterson, Ian C., Yap, Lee Fah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115974/
https://www.ncbi.nlm.nih.gov/pubmed/30060514
http://dx.doi.org/10.3390/cancers10080247
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author Velapasamy, Sharmila
Dawson, Christopher W.
Young, Lawrence S.
Paterson, Ian C.
Yap, Lee Fah
author_facet Velapasamy, Sharmila
Dawson, Christopher W.
Young, Lawrence S.
Paterson, Ian C.
Yap, Lee Fah
author_sort Velapasamy, Sharmila
collection PubMed
description The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.
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spelling pubmed-61159742018-08-31 The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers Velapasamy, Sharmila Dawson, Christopher W. Young, Lawrence S. Paterson, Ian C. Yap, Lee Fah Cancers (Basel) Review The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed. MDPI 2018-07-27 /pmc/articles/PMC6115974/ /pubmed/30060514 http://dx.doi.org/10.3390/cancers10080247 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Velapasamy, Sharmila
Dawson, Christopher W.
Young, Lawrence S.
Paterson, Ian C.
Yap, Lee Fah
The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers
title The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers
title_full The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers
title_fullStr The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers
title_full_unstemmed The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers
title_short The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers
title_sort dynamic roles of tgf-β signalling in ebv-associated cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115974/
https://www.ncbi.nlm.nih.gov/pubmed/30060514
http://dx.doi.org/10.3390/cancers10080247
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