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Computational Feasibility Analysis of Electrochemotherapy With Novel Needle-Electrode Arrays for the Treatment of Invasive Breast Ductal Carcinoma

Breast cancer represents a rising problem concerning public health worldwide. Current efforts are aimed to the development of new minimally invasive and conservative treatment procedures for this disease. A treatment approach for invasive breast ductal carcinoma could be based on electroporation. He...

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Autores principales: Vera-Tizatl, Adriana Leticia, Vera-Tizatl, Claudia Elizabeth, Vera-Hernández, Arturo, Leija-Salas, Lorenzo, Rodríguez, Sergio, Miklavčič, Damijan, Kos, Bor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116067/
https://www.ncbi.nlm.nih.gov/pubmed/30157721
http://dx.doi.org/10.1177/1533033818794939
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author Vera-Tizatl, Adriana Leticia
Vera-Tizatl, Claudia Elizabeth
Vera-Hernández, Arturo
Leija-Salas, Lorenzo
Rodríguez, Sergio
Miklavčič, Damijan
Kos, Bor
author_facet Vera-Tizatl, Adriana Leticia
Vera-Tizatl, Claudia Elizabeth
Vera-Hernández, Arturo
Leija-Salas, Lorenzo
Rodríguez, Sergio
Miklavčič, Damijan
Kos, Bor
author_sort Vera-Tizatl, Adriana Leticia
collection PubMed
description Breast cancer represents a rising problem concerning public health worldwide. Current efforts are aimed to the development of new minimally invasive and conservative treatment procedures for this disease. A treatment approach for invasive breast ductal carcinoma could be based on electroporation. Hence, in order to determine the effectiveness of electrochemotherapy in the treatment of this disease, 12 electrode models were investigated on realistic patient-specific computational breast models of 3 patients diagnosed by Digital Breast Tomosynthesis imaging. The electrode models exhibit 4, 5, and 6 needles arranged in 4 geometric configurations (delta, diamond, and star) and 3 different needle spacing resulting in a total of 12 needle-electrode arrays. Electric field distribution in the tumors and a surrounding safety margin of 1 cm around the tumor edge is computed using the finite element method. Efficiency of the electrode arrays was determined hierarchically based on (1) percentage of tumor volume reversibly electroporated, (2) percentage of tumor volume irreversibly electroporated, (3) percentage of treated safety margin volume, (4) minimal invasiveness, that is, minimal number of electrodes used, (5) minimal activated electrode pairs, and (6) minimal electric current. Results show that 3 electrode arrays (4 needle-delta, 5 needle-diamond, and 6 needle-star) with fixed-geometry configuration could be used in the treatment with electrochemotherapy of invasive breast ductal carcinomas ranging from 1 to 5 cm(3) along with a surrounding safety margin of 1 cm.
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spelling pubmed-61160672018-09-04 Computational Feasibility Analysis of Electrochemotherapy With Novel Needle-Electrode Arrays for the Treatment of Invasive Breast Ductal Carcinoma Vera-Tizatl, Adriana Leticia Vera-Tizatl, Claudia Elizabeth Vera-Hernández, Arturo Leija-Salas, Lorenzo Rodríguez, Sergio Miklavčič, Damijan Kos, Bor Technol Cancer Res Treat Electroporation Based Therapies-Original Article Breast cancer represents a rising problem concerning public health worldwide. Current efforts are aimed to the development of new minimally invasive and conservative treatment procedures for this disease. A treatment approach for invasive breast ductal carcinoma could be based on electroporation. Hence, in order to determine the effectiveness of electrochemotherapy in the treatment of this disease, 12 electrode models were investigated on realistic patient-specific computational breast models of 3 patients diagnosed by Digital Breast Tomosynthesis imaging. The electrode models exhibit 4, 5, and 6 needles arranged in 4 geometric configurations (delta, diamond, and star) and 3 different needle spacing resulting in a total of 12 needle-electrode arrays. Electric field distribution in the tumors and a surrounding safety margin of 1 cm around the tumor edge is computed using the finite element method. Efficiency of the electrode arrays was determined hierarchically based on (1) percentage of tumor volume reversibly electroporated, (2) percentage of tumor volume irreversibly electroporated, (3) percentage of treated safety margin volume, (4) minimal invasiveness, that is, minimal number of electrodes used, (5) minimal activated electrode pairs, and (6) minimal electric current. Results show that 3 electrode arrays (4 needle-delta, 5 needle-diamond, and 6 needle-star) with fixed-geometry configuration could be used in the treatment with electrochemotherapy of invasive breast ductal carcinomas ranging from 1 to 5 cm(3) along with a surrounding safety margin of 1 cm. SAGE Publications 2018-08-29 /pmc/articles/PMC6116067/ /pubmed/30157721 http://dx.doi.org/10.1177/1533033818794939 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Electroporation Based Therapies-Original Article
Vera-Tizatl, Adriana Leticia
Vera-Tizatl, Claudia Elizabeth
Vera-Hernández, Arturo
Leija-Salas, Lorenzo
Rodríguez, Sergio
Miklavčič, Damijan
Kos, Bor
Computational Feasibility Analysis of Electrochemotherapy With Novel Needle-Electrode Arrays for the Treatment of Invasive Breast Ductal Carcinoma
title Computational Feasibility Analysis of Electrochemotherapy With Novel Needle-Electrode Arrays for the Treatment of Invasive Breast Ductal Carcinoma
title_full Computational Feasibility Analysis of Electrochemotherapy With Novel Needle-Electrode Arrays for the Treatment of Invasive Breast Ductal Carcinoma
title_fullStr Computational Feasibility Analysis of Electrochemotherapy With Novel Needle-Electrode Arrays for the Treatment of Invasive Breast Ductal Carcinoma
title_full_unstemmed Computational Feasibility Analysis of Electrochemotherapy With Novel Needle-Electrode Arrays for the Treatment of Invasive Breast Ductal Carcinoma
title_short Computational Feasibility Analysis of Electrochemotherapy With Novel Needle-Electrode Arrays for the Treatment of Invasive Breast Ductal Carcinoma
title_sort computational feasibility analysis of electrochemotherapy with novel needle-electrode arrays for the treatment of invasive breast ductal carcinoma
topic Electroporation Based Therapies-Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116067/
https://www.ncbi.nlm.nih.gov/pubmed/30157721
http://dx.doi.org/10.1177/1533033818794939
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