The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods

BACKGROUND: Polyacrylic acid (PAA)–coated gold nanorods (GNRs) were prepared in this research, and then the structure, stability, temperature increment efficiency, and biocompatibility of GNRs@PAA were detected. METHODS: It was demonstrated that GNRs@PAA coupled with an 808 nm laser had superior eff...

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Autores principales: Pan, Su, Xing, Hongcun, Fu, Xuqi, Yu, Hongmei, Yang, Zhaogang, Yang, Yudan, Sun, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116076/
https://www.ncbi.nlm.nih.gov/pubmed/30181729
http://dx.doi.org/10.1177/1559325818789841
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author Pan, Su
Xing, Hongcun
Fu, Xuqi
Yu, Hongmei
Yang, Zhaogang
Yang, Yudan
Sun, Wei
author_facet Pan, Su
Xing, Hongcun
Fu, Xuqi
Yu, Hongmei
Yang, Zhaogang
Yang, Yudan
Sun, Wei
author_sort Pan, Su
collection PubMed
description BACKGROUND: Polyacrylic acid (PAA)–coated gold nanorods (GNRs) were prepared in this research, and then the structure, stability, temperature increment efficiency, and biocompatibility of GNRs@PAA were detected. METHODS: It was demonstrated that GNRs@PAA coupled with an 808 nm laser had superior efficiency of hyperthermia therapy for MG63 human osteosarcoma cell. RESULTS: The mechanism of photothermal therapy of GNRs@PAA was explored, and it was proved that damaged cell membrane and DNA integration caused cell apoptosis and death, and the cell apoptosis rate had been obviously promoted by in vitro photothermal therapy which exhibited time–dose dependence. CONCLUSION: The results demonstrated that the GNRs@PAA could be a promising candidate for phototherapeutic applications in human osteosarcoma.
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spelling pubmed-61160762018-09-04 The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods Pan, Su Xing, Hongcun Fu, Xuqi Yu, Hongmei Yang, Zhaogang Yang, Yudan Sun, Wei Dose Response Original Article BACKGROUND: Polyacrylic acid (PAA)–coated gold nanorods (GNRs) were prepared in this research, and then the structure, stability, temperature increment efficiency, and biocompatibility of GNRs@PAA were detected. METHODS: It was demonstrated that GNRs@PAA coupled with an 808 nm laser had superior efficiency of hyperthermia therapy for MG63 human osteosarcoma cell. RESULTS: The mechanism of photothermal therapy of GNRs@PAA was explored, and it was proved that damaged cell membrane and DNA integration caused cell apoptosis and death, and the cell apoptosis rate had been obviously promoted by in vitro photothermal therapy which exhibited time–dose dependence. CONCLUSION: The results demonstrated that the GNRs@PAA could be a promising candidate for phototherapeutic applications in human osteosarcoma. SAGE Publications 2018-08-29 /pmc/articles/PMC6116076/ /pubmed/30181729 http://dx.doi.org/10.1177/1559325818789841 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Pan, Su
Xing, Hongcun
Fu, Xuqi
Yu, Hongmei
Yang, Zhaogang
Yang, Yudan
Sun, Wei
The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods
title The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods
title_full The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods
title_fullStr The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods
title_full_unstemmed The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods
title_short The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods
title_sort effect of photothermal therapy on osteosarcoma with polyacrylic acid–coated gold nanorods
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116076/
https://www.ncbi.nlm.nih.gov/pubmed/30181729
http://dx.doi.org/10.1177/1559325818789841
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