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The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species

Eukaryotic cells have evolved signalling pathways that allow adaptation to harmful conditions that disrupt endoplasmic reticulum (ER) homeostasis. When the function of the ER is compromised in a condition known as ER stress, the cell triggers the unfolded protein response (UPR) in order to restore E...

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Autores principales: Hernández-Elvira, Mariana, Torres-Quiroz, Francisco, Escamilla-Ayala, Abril, Domínguez-Martin, Eunice, Escalante, Ricardo, Kawasaki, Laura, Ongay-Larios, Laura, Coria, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116095/
https://www.ncbi.nlm.nih.gov/pubmed/30110882
http://dx.doi.org/10.3390/cells7080106
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author Hernández-Elvira, Mariana
Torres-Quiroz, Francisco
Escamilla-Ayala, Abril
Domínguez-Martin, Eunice
Escalante, Ricardo
Kawasaki, Laura
Ongay-Larios, Laura
Coria, Roberto
author_facet Hernández-Elvira, Mariana
Torres-Quiroz, Francisco
Escamilla-Ayala, Abril
Domínguez-Martin, Eunice
Escalante, Ricardo
Kawasaki, Laura
Ongay-Larios, Laura
Coria, Roberto
author_sort Hernández-Elvira, Mariana
collection PubMed
description Eukaryotic cells have evolved signalling pathways that allow adaptation to harmful conditions that disrupt endoplasmic reticulum (ER) homeostasis. When the function of the ER is compromised in a condition known as ER stress, the cell triggers the unfolded protein response (UPR) in order to restore ER homeostasis. Accumulation of misfolded proteins due to stress conditions activates the UPR pathway. In mammalian cells, the UPR is composed of three branches, each containing an ER sensor (PERK, ATF6 and IRE1). However, in yeast species, the only sensor present is the inositol-requiring enzyme Ire1. To cope with unfolded protein accumulation, Ire1 triggers either a transcriptional response mediated by a transcriptional factor that belongs to the bZIP transcription factor family or an mRNA degradation process. In this review, we address the current knowledge of the UPR pathway in several yeast species: Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida glabrata, Cryptococcus neoformans, and Candida albicans. We also include unpublished data on the UPR pathway of the budding yeast Kluyveromyces lactis. We describe the basic components of the UPR pathway along with similarities and differences in the UPR mechanism that are present in these yeast species.
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spelling pubmed-61160952018-08-31 The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species Hernández-Elvira, Mariana Torres-Quiroz, Francisco Escamilla-Ayala, Abril Domínguez-Martin, Eunice Escalante, Ricardo Kawasaki, Laura Ongay-Larios, Laura Coria, Roberto Cells Review Eukaryotic cells have evolved signalling pathways that allow adaptation to harmful conditions that disrupt endoplasmic reticulum (ER) homeostasis. When the function of the ER is compromised in a condition known as ER stress, the cell triggers the unfolded protein response (UPR) in order to restore ER homeostasis. Accumulation of misfolded proteins due to stress conditions activates the UPR pathway. In mammalian cells, the UPR is composed of three branches, each containing an ER sensor (PERK, ATF6 and IRE1). However, in yeast species, the only sensor present is the inositol-requiring enzyme Ire1. To cope with unfolded protein accumulation, Ire1 triggers either a transcriptional response mediated by a transcriptional factor that belongs to the bZIP transcription factor family or an mRNA degradation process. In this review, we address the current knowledge of the UPR pathway in several yeast species: Saccharomyces cerevisiae, Schizosaccharomyces pombe, Candida glabrata, Cryptococcus neoformans, and Candida albicans. We also include unpublished data on the UPR pathway of the budding yeast Kluyveromyces lactis. We describe the basic components of the UPR pathway along with similarities and differences in the UPR mechanism that are present in these yeast species. MDPI 2018-08-14 /pmc/articles/PMC6116095/ /pubmed/30110882 http://dx.doi.org/10.3390/cells7080106 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hernández-Elvira, Mariana
Torres-Quiroz, Francisco
Escamilla-Ayala, Abril
Domínguez-Martin, Eunice
Escalante, Ricardo
Kawasaki, Laura
Ongay-Larios, Laura
Coria, Roberto
The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species
title The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species
title_full The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species
title_fullStr The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species
title_full_unstemmed The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species
title_short The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species
title_sort unfolded protein response pathway in the yeast kluyveromyces lactis. a comparative view among yeast species
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116095/
https://www.ncbi.nlm.nih.gov/pubmed/30110882
http://dx.doi.org/10.3390/cells7080106
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