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Application of Metabolomic Tools for Studying Low Molecular-Weight Fraction of Animal Venoms and Poisons

Both venoms and poisonous secretions are complex mixtures that assist in defense, predation, communication, and competition in the animal world. They consist of variable bioactive molecules, such as proteins, peptides, salts and also metabolites. Metabolomics opens up new perspectives for the study...

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Autores principales: Klupczynska, Agnieszka, Pawlak, Magdalena, Kokot, Zenon J., Matysiak, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116190/
https://www.ncbi.nlm.nih.gov/pubmed/30042318
http://dx.doi.org/10.3390/toxins10080306
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author Klupczynska, Agnieszka
Pawlak, Magdalena
Kokot, Zenon J.
Matysiak, Jan
author_facet Klupczynska, Agnieszka
Pawlak, Magdalena
Kokot, Zenon J.
Matysiak, Jan
author_sort Klupczynska, Agnieszka
collection PubMed
description Both venoms and poisonous secretions are complex mixtures that assist in defense, predation, communication, and competition in the animal world. They consist of variable bioactive molecules, such as proteins, peptides, salts and also metabolites. Metabolomics opens up new perspectives for the study of venoms and poisons as it gives an opportunity to investigate their previously unexplored low molecular-weight components. The aim of this article is to summarize the available literature where metabolomic technologies were used for examining the composition of animal venoms and poisons. The paper discusses only the low molecular-weight components of venoms and poisons collected from snakes, spiders, scorpions, toads, frogs, and ants. An overview is given of the analytical strategies used in the analysis of the metabolic content of the samples. We paid special attention to the classes of compounds identified in various venoms and poisons and potential applications of the small molecules (especially bufadienolides) discovered. The issues that should be more effectively addressed in the studies of animal venoms and poisons include challenges related to sample collection and preparation, species-related chemical diversity of compounds building the metabolome and a need of an online database that would enhance identification of small molecule components of these secretions.
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spelling pubmed-61161902018-08-31 Application of Metabolomic Tools for Studying Low Molecular-Weight Fraction of Animal Venoms and Poisons Klupczynska, Agnieszka Pawlak, Magdalena Kokot, Zenon J. Matysiak, Jan Toxins (Basel) Review Both venoms and poisonous secretions are complex mixtures that assist in defense, predation, communication, and competition in the animal world. They consist of variable bioactive molecules, such as proteins, peptides, salts and also metabolites. Metabolomics opens up new perspectives for the study of venoms and poisons as it gives an opportunity to investigate their previously unexplored low molecular-weight components. The aim of this article is to summarize the available literature where metabolomic technologies were used for examining the composition of animal venoms and poisons. The paper discusses only the low molecular-weight components of venoms and poisons collected from snakes, spiders, scorpions, toads, frogs, and ants. An overview is given of the analytical strategies used in the analysis of the metabolic content of the samples. We paid special attention to the classes of compounds identified in various venoms and poisons and potential applications of the small molecules (especially bufadienolides) discovered. The issues that should be more effectively addressed in the studies of animal venoms and poisons include challenges related to sample collection and preparation, species-related chemical diversity of compounds building the metabolome and a need of an online database that would enhance identification of small molecule components of these secretions. MDPI 2018-07-24 /pmc/articles/PMC6116190/ /pubmed/30042318 http://dx.doi.org/10.3390/toxins10080306 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Klupczynska, Agnieszka
Pawlak, Magdalena
Kokot, Zenon J.
Matysiak, Jan
Application of Metabolomic Tools for Studying Low Molecular-Weight Fraction of Animal Venoms and Poisons
title Application of Metabolomic Tools for Studying Low Molecular-Weight Fraction of Animal Venoms and Poisons
title_full Application of Metabolomic Tools for Studying Low Molecular-Weight Fraction of Animal Venoms and Poisons
title_fullStr Application of Metabolomic Tools for Studying Low Molecular-Weight Fraction of Animal Venoms and Poisons
title_full_unstemmed Application of Metabolomic Tools for Studying Low Molecular-Weight Fraction of Animal Venoms and Poisons
title_short Application of Metabolomic Tools for Studying Low Molecular-Weight Fraction of Animal Venoms and Poisons
title_sort application of metabolomic tools for studying low molecular-weight fraction of animal venoms and poisons
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116190/
https://www.ncbi.nlm.nih.gov/pubmed/30042318
http://dx.doi.org/10.3390/toxins10080306
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