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Ca(2+) Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations
Heart failure (HF) is characterized by altered Ca(2+) cycling, resulting in cardiac contractile dysfunction. Failing myocytes undergo electrophysiological remodeling, which is known to be the main cause of abnormal Ca(2+) homeostasis. However, structural remodeling, specifically proliferating fibrob...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116328/ https://www.ncbi.nlm.nih.gov/pubmed/30190684 http://dx.doi.org/10.3389/fphys.2018.01194 |