Integration Mapping of piggyBac-Mediated CD19 Chimeric Antigen Receptor T Cells Analyzed by Novel Tagmentation-Assisted PCR

Insertional mutagenesis is an important risk with all genetically modified cell therapies, including chimeric antigen receptor (CAR)-T cell therapy used for hematological malignancies. Here we describe a new tagmentation-assisted PCR (tag-PCR) system that can determine the integration sites of trans...

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Detalles Bibliográficos
Autores principales: Hamada, Motoharu, Nishio, Nobuhiro, Okuno, Yusuke, Suzuki, Satoshi, Kawashima, Nozomu, Muramatsu, Hideki, Tsubota, Shoma, Wilson, Matthew H., Morita, Daisuke, Kataoka, Shinsuke, Ichikawa, Daisuke, Murakami, Norihiro, Taniguchi, Rieko, Suzuki, Kyogo, Kojima, Daiei, Sekiya, Yuko, Nishikawa, Eri, Narita, Atsushi, Hama, Asahito, Kojima, Seiji, Nakazawa, Yozo, Takahashi, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116345/
https://www.ncbi.nlm.nih.gov/pubmed/30082227
http://dx.doi.org/10.1016/j.ebiom.2018.07.008

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