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Detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound

BACKGROUND: This study aimed to determine whether, besides carotid ultrasound (US), a lateral lumbar spine radiography may also help identify ankylosing spondylitis (AS) patients at high risk of cardiovascular (CV) disease. METHODS: A set of 125 AS patients older than 35 years without a history of C...

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Autores principales: Rueda-Gotor, Javier, Genre, Fernanda, Corrales, Alfonso, Blanco, Ricardo, Fuentevilla, Patricia, Portilla, Virginia, Expósito, Rosa, Mata, Cristina, Pina, Trinitario, González-Juanatey, Carlos, Rodriguez-Rodriguez, Luis, González-Gay, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116452/
https://www.ncbi.nlm.nih.gov/pubmed/30157925
http://dx.doi.org/10.1186/s13075-018-1684-y
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author Rueda-Gotor, Javier
Genre, Fernanda
Corrales, Alfonso
Blanco, Ricardo
Fuentevilla, Patricia
Portilla, Virginia
Expósito, Rosa
Mata, Cristina
Pina, Trinitario
González-Juanatey, Carlos
Rodriguez-Rodriguez, Luis
González-Gay, Miguel A.
author_facet Rueda-Gotor, Javier
Genre, Fernanda
Corrales, Alfonso
Blanco, Ricardo
Fuentevilla, Patricia
Portilla, Virginia
Expósito, Rosa
Mata, Cristina
Pina, Trinitario
González-Juanatey, Carlos
Rodriguez-Rodriguez, Luis
González-Gay, Miguel A.
author_sort Rueda-Gotor, Javier
collection PubMed
description BACKGROUND: This study aimed to determine whether, besides carotid ultrasound (US), a lateral lumbar spine radiography may also help identify ankylosing spondylitis (AS) patients at high risk of cardiovascular (CV) disease. METHODS: A set of 125 AS patients older than 35 years without a history of CV events, diabetes mellitus, or chronic kidney disease was recruited. Carotid US and lateral lumbar spine radiography were performed in all of them. The CV risk was calculated according to the total cholesterol systematic coronary risk evaluation (TC-SCORE) algorithm. Presence of carotid plaques was defined following the Mannheim Carotid Intima-media Thickness and Plaque Consensus. Abdominal aortic calcium (AAC) in a plain radiography was defined as calcific densities visible in an area parallel and anterior to the lumbar spine. RESULTS: Carotid US showed higher sensitivity than lateral lumbar spine radiography to detect high CV risk in the 54 patients with moderate TC-SCORE (61% versus 38.9%). Using carotid plaques as the gold standard test, a predictive model that included a TC-SCORE ≥ 5% or the presence of AAC in the lateral lumbar spine radiography in patients with both moderate and low CV risk (< 5%) according to the TC-SCORE yielded a sensitivity of 50.9% with a specificity of 95.7% to identify high/very high CV-risk AS patients. A positive correlation between AAC and carotid plaques was observed (r(2) = 0.49, p < 0.001). CONCLUSIONS: A lateral lumbar spine radiography is a useful tool to identify patients with AS at high risk of CV disease.
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spelling pubmed-61164522018-09-04 Detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound Rueda-Gotor, Javier Genre, Fernanda Corrales, Alfonso Blanco, Ricardo Fuentevilla, Patricia Portilla, Virginia Expósito, Rosa Mata, Cristina Pina, Trinitario González-Juanatey, Carlos Rodriguez-Rodriguez, Luis González-Gay, Miguel A. Arthritis Res Ther Research Article BACKGROUND: This study aimed to determine whether, besides carotid ultrasound (US), a lateral lumbar spine radiography may also help identify ankylosing spondylitis (AS) patients at high risk of cardiovascular (CV) disease. METHODS: A set of 125 AS patients older than 35 years without a history of CV events, diabetes mellitus, or chronic kidney disease was recruited. Carotid US and lateral lumbar spine radiography were performed in all of them. The CV risk was calculated according to the total cholesterol systematic coronary risk evaluation (TC-SCORE) algorithm. Presence of carotid plaques was defined following the Mannheim Carotid Intima-media Thickness and Plaque Consensus. Abdominal aortic calcium (AAC) in a plain radiography was defined as calcific densities visible in an area parallel and anterior to the lumbar spine. RESULTS: Carotid US showed higher sensitivity than lateral lumbar spine radiography to detect high CV risk in the 54 patients with moderate TC-SCORE (61% versus 38.9%). Using carotid plaques as the gold standard test, a predictive model that included a TC-SCORE ≥ 5% or the presence of AAC in the lateral lumbar spine radiography in patients with both moderate and low CV risk (< 5%) according to the TC-SCORE yielded a sensitivity of 50.9% with a specificity of 95.7% to identify high/very high CV-risk AS patients. A positive correlation between AAC and carotid plaques was observed (r(2) = 0.49, p < 0.001). CONCLUSIONS: A lateral lumbar spine radiography is a useful tool to identify patients with AS at high risk of CV disease. BioMed Central 2018-08-29 2018 /pmc/articles/PMC6116452/ /pubmed/30157925 http://dx.doi.org/10.1186/s13075-018-1684-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Rueda-Gotor, Javier
Genre, Fernanda
Corrales, Alfonso
Blanco, Ricardo
Fuentevilla, Patricia
Portilla, Virginia
Expósito, Rosa
Mata, Cristina
Pina, Trinitario
González-Juanatey, Carlos
Rodriguez-Rodriguez, Luis
González-Gay, Miguel A.
Detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound
title Detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound
title_full Detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound
title_fullStr Detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound
title_full_unstemmed Detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound
title_short Detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound
title_sort detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116452/
https://www.ncbi.nlm.nih.gov/pubmed/30157925
http://dx.doi.org/10.1186/s13075-018-1684-y
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