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Tofacitinib inhibits granulocyte–macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils

BACKGROUND: Granulocyte–macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine that activates myeloid cells to initiate tissue inflammation. However, the molecular actions of GM-CSF against innate immunity are still poorly characterized. Here, we investigated the in vitro ef...

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Detalles Bibliográficos
Autores principales:	Furuya, Makiko Yashiro, Asano, Tomoyuki, Sumichika, Yuya, Sato, Shuzo, Kobayashi, Hiroko, Watanabe, Hiroshi, Suzuki, Eiji, Kozuru, Hideko, Yatsuhashi, Hiroshi, Koga, Tomohiro, Ohira, Hiromasa, Sekine, Hideharu, Kawakami, Atsushi, Migita, Kiyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116484/ https://www.ncbi.nlm.nih.gov/pubmed/30157949 http://dx.doi.org/10.1186/s13075-018-1685-x

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