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Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination
BACKGROUND: Maraviroc-containing combined antiretroviral therapy (MVC-cART) improved the response to the hepatitis B virus (HBV) vaccine in HIV-infected subjects younger than 50 years old. We aimed here to explore the effect of this antiretroviral therapy on different immunological parameters that c...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116502/ https://www.ncbi.nlm.nih.gov/pubmed/30157873 http://dx.doi.org/10.1186/s12967-018-1617-1 |
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author | Herrero-Fernández, Inés Rosado-Sánchez, Isaac Genebat, Miguel Tarancón-Díez, Laura Rodríguez-Méndez, María Mar Pozo-Balado, María Mar Lozano, Carmen Ruiz-Mateos, Ezequiel Leal, Manuel Pacheco, Yolanda M. |
author_facet | Herrero-Fernández, Inés Rosado-Sánchez, Isaac Genebat, Miguel Tarancón-Díez, Laura Rodríguez-Méndez, María Mar Pozo-Balado, María Mar Lozano, Carmen Ruiz-Mateos, Ezequiel Leal, Manuel Pacheco, Yolanda M. |
author_sort | Herrero-Fernández, Inés |
collection | PubMed |
description | BACKGROUND: Maraviroc-containing combined antiretroviral therapy (MVC-cART) improved the response to the hepatitis B virus (HBV) vaccine in HIV-infected subjects younger than 50 years old. We aimed here to explore the effect of this antiretroviral therapy on different immunological parameters that could account for this effect. METHODS: We analysed baseline samples of vaccinated subjects under 50 years old (n = 41). We characterized the maturational subsets and the expression of activation, senescence and prone-to-apoptosis markers on CD4 T-cells; we also quantified T-regulatory cells (Treg) and dendritic cell (DC) subsets. We used binary logistic regression to evaluate the immunological impact of MVC-cART, correlation with MVC exposure and linear regression for association with the magnitude of the HBV vaccine response. RESULTS: HIV-infected subjects on MVC-cART prior to vaccination showed increased recent thymic emigrants levels and reduced myeloid-DC levels. A longer exposure to MVC-cART was associated with lower frequencies of Tregs and activated and proliferating CD4 T-cells. Furthermore, the frequencies of activated and proliferating CD4 T-cells were inversely associated with the magnitude of the HBV vaccine response. CONCLUSION: The beneficial effect of MVC-cART in the HBV vaccine response in subjects below 50 years old could be partially mediated by its reducing effect on the frequencies of activated and proliferating CD4 T-cells prior to vaccination. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12967-018-1617-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6116502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61165022018-10-02 Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination Herrero-Fernández, Inés Rosado-Sánchez, Isaac Genebat, Miguel Tarancón-Díez, Laura Rodríguez-Méndez, María Mar Pozo-Balado, María Mar Lozano, Carmen Ruiz-Mateos, Ezequiel Leal, Manuel Pacheco, Yolanda M. J Transl Med Research BACKGROUND: Maraviroc-containing combined antiretroviral therapy (MVC-cART) improved the response to the hepatitis B virus (HBV) vaccine in HIV-infected subjects younger than 50 years old. We aimed here to explore the effect of this antiretroviral therapy on different immunological parameters that could account for this effect. METHODS: We analysed baseline samples of vaccinated subjects under 50 years old (n = 41). We characterized the maturational subsets and the expression of activation, senescence and prone-to-apoptosis markers on CD4 T-cells; we also quantified T-regulatory cells (Treg) and dendritic cell (DC) subsets. We used binary logistic regression to evaluate the immunological impact of MVC-cART, correlation with MVC exposure and linear regression for association with the magnitude of the HBV vaccine response. RESULTS: HIV-infected subjects on MVC-cART prior to vaccination showed increased recent thymic emigrants levels and reduced myeloid-DC levels. A longer exposure to MVC-cART was associated with lower frequencies of Tregs and activated and proliferating CD4 T-cells. Furthermore, the frequencies of activated and proliferating CD4 T-cells were inversely associated with the magnitude of the HBV vaccine response. CONCLUSION: The beneficial effect of MVC-cART in the HBV vaccine response in subjects below 50 years old could be partially mediated by its reducing effect on the frequencies of activated and proliferating CD4 T-cells prior to vaccination. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12967-018-1617-1) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-29 /pmc/articles/PMC6116502/ /pubmed/30157873 http://dx.doi.org/10.1186/s12967-018-1617-1 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Herrero-Fernández, Inés Rosado-Sánchez, Isaac Genebat, Miguel Tarancón-Díez, Laura Rodríguez-Méndez, María Mar Pozo-Balado, María Mar Lozano, Carmen Ruiz-Mateos, Ezequiel Leal, Manuel Pacheco, Yolanda M. Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination |
title | Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination |
title_full | Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination |
title_fullStr | Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination |
title_full_unstemmed | Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination |
title_short | Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination |
title_sort | improved cd4 t cell profile in hiv-infected subjects on maraviroc-containing therapy is associated with better responsiveness to hbv vaccination |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116502/ https://www.ncbi.nlm.nih.gov/pubmed/30157873 http://dx.doi.org/10.1186/s12967-018-1617-1 |
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