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Synchronous polypectomy during endoscopic diagnosis of colorectal cancer – is the risk of tumour implantation at the polypectomy site significant?
BACKGROUND: Synchronous polypectomy in colonic malignancies is contentious due to the perceived risks of tumour implantation at polypectomy sites (PS). We assess the risks of tumour implantation after synchronous polypectomy. METHODS: An analysis of all endoscopies for cancer that were accompanied b...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116547/ https://www.ncbi.nlm.nih.gov/pubmed/30157767 http://dx.doi.org/10.1186/s12876-018-0861-4 |
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author | Tan, W. J. Ng, N. ZP. Chen, Y. D. Chee, Y. H. M. Foo, F. J. Tang, C. L. Chew, M. H. |
author_facet | Tan, W. J. Ng, N. ZP. Chen, Y. D. Chee, Y. H. M. Foo, F. J. Tang, C. L. Chew, M. H. |
author_sort | Tan, W. J. |
collection | PubMed |
description | BACKGROUND: Synchronous polypectomy in colonic malignancies is contentious due to the perceived risks of tumour implantation at polypectomy sites (PS). We assess the risks of tumour implantation after synchronous polypectomy. METHODS: An analysis of all endoscopies for cancer that were accompanied by synchronous polypectomies from 2005 to 2009 was performed. The incidence of metachronous colorectal cancers located at the same segment of a previous PS was the surrogate for tumour implantation. Data on patient demographics, tumour and polyp location(s) and follow-up outcomes were extracted. The rate of metachronous lesions at the same segment of a previous PS between patients who had all synchronous PS resected (Group A) and patients with PS left in-situ (Group B) were compared. RESULTS: Two hundred and eighty-four patients had synchronous polypectomy performed during their initial endoscopy for cancer. Three patients were lost to follow-up and, in the remaining 281 patients, 87 (31.0%) were in Group A while 194 (69%) were in Group B. Median age, gender, tumour location, tumour stage, and pathological characteristics were similar between both groups. 2 (0.7%) patients developed local recurrences. Six (2.1%) patients developed metachronous lesions, four of which were located at the same segment where synchronous polypectomy was previously performed. The rates of metachronous lesions at the PS in groups A and B were similar at 1.1% (1/87) and 1.5% (3/194), respectively (p = 0.795). CONCLUSION: Malignant implantation after synchronous polypectomy in the setting of a newly diagnosed cancer remains unproven. Even if tumor implantation did occur, the incidence is likely low. |
format | Online Article Text |
id | pubmed-6116547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61165472018-10-02 Synchronous polypectomy during endoscopic diagnosis of colorectal cancer – is the risk of tumour implantation at the polypectomy site significant? Tan, W. J. Ng, N. ZP. Chen, Y. D. Chee, Y. H. M. Foo, F. J. Tang, C. L. Chew, M. H. BMC Gastroenterol Research Article BACKGROUND: Synchronous polypectomy in colonic malignancies is contentious due to the perceived risks of tumour implantation at polypectomy sites (PS). We assess the risks of tumour implantation after synchronous polypectomy. METHODS: An analysis of all endoscopies for cancer that were accompanied by synchronous polypectomies from 2005 to 2009 was performed. The incidence of metachronous colorectal cancers located at the same segment of a previous PS was the surrogate for tumour implantation. Data on patient demographics, tumour and polyp location(s) and follow-up outcomes were extracted. The rate of metachronous lesions at the same segment of a previous PS between patients who had all synchronous PS resected (Group A) and patients with PS left in-situ (Group B) were compared. RESULTS: Two hundred and eighty-four patients had synchronous polypectomy performed during their initial endoscopy for cancer. Three patients were lost to follow-up and, in the remaining 281 patients, 87 (31.0%) were in Group A while 194 (69%) were in Group B. Median age, gender, tumour location, tumour stage, and pathological characteristics were similar between both groups. 2 (0.7%) patients developed local recurrences. Six (2.1%) patients developed metachronous lesions, four of which were located at the same segment where synchronous polypectomy was previously performed. The rates of metachronous lesions at the PS in groups A and B were similar at 1.1% (1/87) and 1.5% (3/194), respectively (p = 0.795). CONCLUSION: Malignant implantation after synchronous polypectomy in the setting of a newly diagnosed cancer remains unproven. Even if tumor implantation did occur, the incidence is likely low. BioMed Central 2018-08-29 /pmc/articles/PMC6116547/ /pubmed/30157767 http://dx.doi.org/10.1186/s12876-018-0861-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Tan, W. J. Ng, N. ZP. Chen, Y. D. Chee, Y. H. M. Foo, F. J. Tang, C. L. Chew, M. H. Synchronous polypectomy during endoscopic diagnosis of colorectal cancer – is the risk of tumour implantation at the polypectomy site significant? |
title | Synchronous polypectomy during endoscopic diagnosis of colorectal cancer – is the risk of tumour implantation at the polypectomy site significant? |
title_full | Synchronous polypectomy during endoscopic diagnosis of colorectal cancer – is the risk of tumour implantation at the polypectomy site significant? |
title_fullStr | Synchronous polypectomy during endoscopic diagnosis of colorectal cancer – is the risk of tumour implantation at the polypectomy site significant? |
title_full_unstemmed | Synchronous polypectomy during endoscopic diagnosis of colorectal cancer – is the risk of tumour implantation at the polypectomy site significant? |
title_short | Synchronous polypectomy during endoscopic diagnosis of colorectal cancer – is the risk of tumour implantation at the polypectomy site significant? |
title_sort | synchronous polypectomy during endoscopic diagnosis of colorectal cancer – is the risk of tumour implantation at the polypectomy site significant? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116547/ https://www.ncbi.nlm.nih.gov/pubmed/30157767 http://dx.doi.org/10.1186/s12876-018-0861-4 |
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