Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma

Most human cancers arise from stem and progenitor cells by the sequential accumulation of genetic and epigenetic alterations, while cancer modeling typically requires simultaneous multiple oncogenic events. Here, we show that a single p53 mutation, despite causing no defect in the mouse brain, promo...

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Detalles Bibliográficos
Autores principales: Akgül, Seçkin, Li, Yinghua, Zheng, Siyuan, Kool, Marcel, Treisman, Daniel M., Li, Chaoyang, Wang, Yuan, Gröbner, Susanne, Ikenoue, Tsuneo, Shen, Yiping, Camelo-Piragua, Sandra, Tomasek, Gerald, Stark, Sebastian, Guduguntla, Vinay, Gusella, James F., Guan, Kun-Liang, Pfister, Stefan M., Verhaak, Roel G.W., Zhu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116735/
https://www.ncbi.nlm.nih.gov/pubmed/29996106
http://dx.doi.org/10.1016/j.celrep.2018.06.050

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