Cargando…
The naturally occurring xanthone α-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells
Small cell lung cancer (NSCLC) accounts for 85% of total deaths globally, and recent studies indicate the increasing risks of NSCLC in China and South Asian countries. Hence, development of new therapeutics against NSCLC has been a major concern. α-Mangostin, a naturally occurring xanthone, found ab...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116860/ https://www.ncbi.nlm.nih.gov/pubmed/30174507 http://dx.doi.org/10.1016/j.sjbs.2017.03.005 |
_version_ | 1783351663179857920 |
---|---|
author | Zhang, Chunyun Yu, Guifang Shen, Yifeng |
author_facet | Zhang, Chunyun Yu, Guifang Shen, Yifeng |
author_sort | Zhang, Chunyun |
collection | PubMed |
description | Small cell lung cancer (NSCLC) accounts for 85% of total deaths globally, and recent studies indicate the increasing risks of NSCLC in China and South Asian countries. Hence, development of new therapeutics against NSCLC has been a major concern. α-Mangostin, a naturally occurring xanthone, found abundantly in pericarps of mangosteen fruit is well known for its medicinal importance. The anticancer properties of α-mangostin against several types of cancer are also well documented. But the mechanism of action of α-mangostin against lung cancer is not well understood and requires further investigation. Therefore in the present study, we explored the therapeutic potential of α-mangostin against A549 cells. Treatment of A549 cells with α-mangostin resulted in a dose-dependent loss of cell viability, while the non-malignant cells such as hPBMC and WI-38 remained unaffected. Further we observed that the ROS plays an important role in α-mangostin -induced apoptosis in A549 cells, and administration of N-acetyl cysteine significantly abrogates α-mangostin -mediated cytotoxicity in lung cancer cells. Overall, α-mangostin induces ROS-mediated cytotoxicity in NSCLC cells. |
format | Online Article Text |
id | pubmed-6116860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-61168602018-08-31 The naturally occurring xanthone α-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells Zhang, Chunyun Yu, Guifang Shen, Yifeng Saudi J Biol Sci Article Small cell lung cancer (NSCLC) accounts for 85% of total deaths globally, and recent studies indicate the increasing risks of NSCLC in China and South Asian countries. Hence, development of new therapeutics against NSCLC has been a major concern. α-Mangostin, a naturally occurring xanthone, found abundantly in pericarps of mangosteen fruit is well known for its medicinal importance. The anticancer properties of α-mangostin against several types of cancer are also well documented. But the mechanism of action of α-mangostin against lung cancer is not well understood and requires further investigation. Therefore in the present study, we explored the therapeutic potential of α-mangostin against A549 cells. Treatment of A549 cells with α-mangostin resulted in a dose-dependent loss of cell viability, while the non-malignant cells such as hPBMC and WI-38 remained unaffected. Further we observed that the ROS plays an important role in α-mangostin -induced apoptosis in A549 cells, and administration of N-acetyl cysteine significantly abrogates α-mangostin -mediated cytotoxicity in lung cancer cells. Overall, α-mangostin induces ROS-mediated cytotoxicity in NSCLC cells. Elsevier 2018-09 2017-03-14 /pmc/articles/PMC6116860/ /pubmed/30174507 http://dx.doi.org/10.1016/j.sjbs.2017.03.005 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Zhang, Chunyun Yu, Guifang Shen, Yifeng The naturally occurring xanthone α-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells |
title | The naturally occurring xanthone α-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells |
title_full | The naturally occurring xanthone α-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells |
title_fullStr | The naturally occurring xanthone α-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells |
title_full_unstemmed | The naturally occurring xanthone α-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells |
title_short | The naturally occurring xanthone α-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells |
title_sort | naturally occurring xanthone α-mangostin induces ros-mediated cytotoxicity in non-small scale lung cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116860/ https://www.ncbi.nlm.nih.gov/pubmed/30174507 http://dx.doi.org/10.1016/j.sjbs.2017.03.005 |
work_keys_str_mv | AT zhangchunyun thenaturallyoccurringxanthoneamangostininducesrosmediatedcytotoxicityinnonsmallscalelungcancercells AT yuguifang thenaturallyoccurringxanthoneamangostininducesrosmediatedcytotoxicityinnonsmallscalelungcancercells AT shenyifeng thenaturallyoccurringxanthoneamangostininducesrosmediatedcytotoxicityinnonsmallscalelungcancercells AT zhangchunyun naturallyoccurringxanthoneamangostininducesrosmediatedcytotoxicityinnonsmallscalelungcancercells AT yuguifang naturallyoccurringxanthoneamangostininducesrosmediatedcytotoxicityinnonsmallscalelungcancercells AT shenyifeng naturallyoccurringxanthoneamangostininducesrosmediatedcytotoxicityinnonsmallscalelungcancercells |