An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model

EBV causes human B-cell lymphomas and transforms B cells in vitro. EBNA3C, an EBV protein expressed in latently-infected cells, is required for EBV transformation of B cells in vitro. While EBNA3C undoubtedly plays a key role in allowing EBV to successfully infect B cells, many EBV+ lymphomas do not...

Descripción completa

Detalles Bibliográficos
Autores principales: Romero-Masters, James C., Ohashi, Makoto, Djavadian, Reza, Eichelberg, Mark R., Hayes, Mitch, Bristol, Jillian A., Ma, Shidong, Ranheim, Erik A., Gumperz, Jenny, Johannsen, Eric C., Kenney, Shannon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117096/
https://www.ncbi.nlm.nih.gov/pubmed/30125329
http://dx.doi.org/10.1371/journal.ppat.1007221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117096/
https://www.ncbi.nlm.nih.gov/pubmed/30125329
http://dx.doi.org/10.1371/journal.ppat.1007221

Ejemplares similares