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SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue
SERINC5 is a host restriction factor that impairs infectivity of HIV-1 and other primate lentiviruses and is counteracted by the viral accessory protein Nef. However, the importance of SERINC5 antagonism for viral replication and cytopathicity remained unclear. Here, we show that the Nef protein of...
Autores principales: | Kmiec, Dorota, Akbil, Bengisu, Ananth, Swetha, Hotter, Dominik, Sparrer, Konstantin M. J., Stürzel, Christina M., Trautz, Birthe, Ayouba, Ahidjo, Peeters, Martine, Yao, Zhong, Stagljar, Igor, Passos, Vânia, Zillinger, Thomas, Goffinet, Christine, Sauter, Daniel, Fackler, Oliver T., Kirchhoff, Frank |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117100/ https://www.ncbi.nlm.nih.gov/pubmed/30125328 http://dx.doi.org/10.1371/journal.ppat.1007269 |
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