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Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death

Tryparedoxin peroxidases, distant relatives of glutathione peroxidase 4 in higher eukaryotes, are responsible for the detoxification of lipid-derived hydroperoxides in African trypanosomes. The lethal phenotype of procyclic Trypanosoma brucei that lack the enzymes fulfils all criteria defining a for...

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Detalles Bibliográficos
Autores principales:	Bogacz, Marta, Krauth-Siegel, R Luise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117152/ https://www.ncbi.nlm.nih.gov/pubmed/30047863 http://dx.doi.org/10.7554/eLife.37503

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