Genome-wide hypomethylation of LINE-1 and Alu retroelements in cell-free DNA of blood is an epigenetic biomarker of human aging

Aging associated DNA hypomethylation of LINE-1 and Alu retroelements may be a crucial determinant of loss of genomic integrity, deterioration and cancer. In peripheral blood LINE-1 hypomethylation has been reported to increase during aging, but other studies did not observe significant changes. We h...

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Detalles Bibliográficos
Autores principales: Erichsen, Lars, Beermann, Agnes, Arauzo-Bravo, Marcos J., Hassan, Mohamed, Dkhil, Mohamed A., Al-Quraishy, Saleh, Hafiz, Taghreed A., Fischer, Johannes C., Santourlidis, Simeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117241/
https://www.ncbi.nlm.nih.gov/pubmed/30174526
http://dx.doi.org/10.1016/j.sjbs.2018.02.005

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