Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

Anoikis is a form of apoptosis induced by cell detachment. Integrin inactivation plays a major role in the process but the exact signalling pathway is ill-defined. Here we identify an anoikis pathway using gliotoxin (GT), a virulence factor of the fungus Aspergillus fumigatus, which causes invasive...

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Detalles Bibliográficos
Autores principales: Haun, Florian, Neumann, Simon, Peintner, Lukas, Wieland, Katrin, Habicht, Jüri, Schwan, Carsten, Østevold, Kristine, Koczorowska, Maria Magdalena, Biniossek, Martin, Kist, Matthias, Busch, Hauke, Boerries, Melanie, Davis, Roger J., Maurer, Ulrich, Schilling, Oliver, Aktories, Klaus, Borner, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117259/
https://www.ncbi.nlm.nih.gov/pubmed/30166526
http://dx.doi.org/10.1038/s41467-018-05850-w

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