A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase

The catalytic mechanism of the cyclic amidohydrolase isatin hydrolase depends on a catalytically active manganese in the substrate-binding pocket. The Mn(2+) ion is bound by a motif also present in other metal dependent hydrolases like the bacterial kynurenine formamidase. The crystal structures of...

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Detalles Bibliográficos
Autores principales: Sommer, Theis, Bjerregaard-Andersen, Kaare, Uribe, Lalita, Etzerodt, Michael, Diezemann, Gregor, Gauss, Jürgen, Cascella, Michele, Morth, J. Preben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117287/
https://www.ncbi.nlm.nih.gov/pubmed/30166577
http://dx.doi.org/10.1038/s41598-018-31259-y

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