Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Pre-leukemic stem cells (pre-LSCs) give rise to leukemic stem cells through acquisition of additional gene mutations and are an important source of relapse following chemotherapy. We postulated that cell-cycle kinetics of pre-LSCs may be an important determinant of clonal evolution and therapeutic r...

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Detalles Bibliográficos
Autores principales: Tremblay, Cedric S., Saw, Jesslyn, Chiu, Sung Kai, Wong, Nicholas C., Tsyganov, Kirill, Ghotb, Sarah, Graham, Alison N., Yan, Feng, Guirguis, Andrew A., Sonderegger, Stefan E., Lee, Nicole, Kalitsis, Paul, Reynolds, John, Ting, Stephen B., Powell, David R., Jane, Stephen M., Curtis, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117297/
https://www.ncbi.nlm.nih.gov/pubmed/30166543
http://dx.doi.org/10.1038/s41467-018-06021-7

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