Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates

The role of the influenza virus polymerase complex in host range restriction has been well-studied and several host range determinants, such as the polymerase PB2-E627K and PB2-D701N mutations, have been identified. However, there may be additional, currently unknown, human adaptation polymerase mut...

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Detalles Bibliográficos
Autores principales: Arai, Yasuha, Kawashita, Norihito, Hotta, Kozue, Hoang, Phuong Vu Mai, Nguyen, Hang Le Khanh, Nguyen, Thach Co, Vuong, Cuong Duc, Le, Thanh Thi, Le, Mai Thi Quynh, Soda, Kosuke, Ibrahim, Madiha S., Daidoji, Tomo, Takagi, Tatsuya, Shioda, Tatsuo, Nakaya, Takaaki, Ito, Toshihiro, Hasebe, Futoshi, Watanabe, Yohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117316/
https://www.ncbi.nlm.nih.gov/pubmed/30166556
http://dx.doi.org/10.1038/s41598-018-31397-3

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