Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons

The implication of the microtubule-associated protein (MAP) Tau in the ocular manifestations of Alzheimer’s disease (AD) is elusive due to the lack of relevant animal model. However, signs of AD have been reported in the brain of transgenic mice expressing human Tau (hTau). To assess whether hTau is...

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Detalles Bibliográficos
Autores principales: Rodriguez, Léa, Mdzomba, Julius Baya, Joly, Sandrine, Boudreau-Laprise, Mélissa, Planel, Emmanuel, Pernet, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117378/
https://www.ncbi.nlm.nih.gov/pubmed/30197586
http://dx.doi.org/10.3389/fnmol.2018.00293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117378/
https://www.ncbi.nlm.nih.gov/pubmed/30197586
http://dx.doi.org/10.3389/fnmol.2018.00293

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