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The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China

Background: Anxiety and depression continue to be significant comorbidities for people with HIV infection. We investigated the prevalence of and factors associated with anxiety and depression among adult HIV-infected patients across China. Methods: In this cross-sectional study, we described clinica...

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Autores principales: Huang, Xiaojie, Meyers, Kathrine, Liu, Xinchao, Li, Xia, Zhang, Tong, Xia, Wei, Hou, Jiahua, Song, Aixin, He, Haolan, Li, Chongxi, He, Shenghua, Cai, Weiping, Zhong, Huolin, Huang, Chengyu, Liu, Shuiqing, Wang, Hui, Ling, Xuemei, Ma, Ping, Ye, Rongxia, Xiao, Gang, Li, Taisheng, Ding, Ding, Yaffe, Kristine, Chen, Hui, Chen, Yaokai, Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117419/
https://www.ncbi.nlm.nih.gov/pubmed/30197608
http://dx.doi.org/10.3389/fpsyt.2018.00384
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author Huang, Xiaojie
Meyers, Kathrine
Liu, Xinchao
Li, Xia
Zhang, Tong
Xia, Wei
Hou, Jiahua
Song, Aixin
He, Haolan
Li, Chongxi
He, Shenghua
Cai, Weiping
Zhong, Huolin
Huang, Chengyu
Liu, Shuiqing
Wang, Hui
Ling, Xuemei
Ma, Ping
Ye, Rongxia
Xiao, Gang
Li, Taisheng
Ding, Ding
Yaffe, Kristine
Chen, Hui
Chen, Yaokai
Wu, Hao
author_facet Huang, Xiaojie
Meyers, Kathrine
Liu, Xinchao
Li, Xia
Zhang, Tong
Xia, Wei
Hou, Jiahua
Song, Aixin
He, Haolan
Li, Chongxi
He, Shenghua
Cai, Weiping
Zhong, Huolin
Huang, Chengyu
Liu, Shuiqing
Wang, Hui
Ling, Xuemei
Ma, Ping
Ye, Rongxia
Xiao, Gang
Li, Taisheng
Ding, Ding
Yaffe, Kristine
Chen, Hui
Chen, Yaokai
Wu, Hao
author_sort Huang, Xiaojie
collection PubMed
description Background: Anxiety and depression continue to be significant comorbidities for people with HIV infection. We investigated the prevalence of and factors associated with anxiety and depression among adult HIV-infected patients across China. Methods: In this cross-sectional study, we described clinical and psychosocial variables related to depression and anxiety in 4103 HIV-infected persons. Doctors assessed anxiety and depression by asking patients whether they had experienced anxiety or depression in the prior month. Patients also self-administered the Hospital Anxiety and Depression (HAD) scale; those with score ≥8 on HAD-A/D were considered to be at high risk of anxiety or depression. Results: Associations between socio-demographic, psychosocial, and ART-related clinical factors and risk of depression or anxiety were investigated using multivariable logistic regression. Among patients assessed between 9/2014 and 11/2015, 27.4% had symptoms of anxiety, 32.9% had symptoms of depression, and 19.0% had both. Recentness of HIV diagnoses (P = 0.046) was associated with elevated odds of anxiety. Older age (P = 0.004), higher educational attainment (P < 0.001), employment (P = 0.001), support from family / friends (P < 0.001), and sleep disturbance (P < 0.001), and number of ART regimen switches (P = 0.046) were associated with risk of depression, while neither sex nor transmission route showed any associations. There were no significant associations with HIV-specific clinical factors including current CD4(+) T cell count and current viral load. Conclusions: Prevalence of symptoms of anxiety and depression is high in this cohort of treatment-experienced HIV patients. Psychological and social-demographic factors, rather than HIV disease status, were associated with risk of depression and anxiety. This finding highlights the need to deliver interventions to address the mental health issues affecting HIV-infected persons with fully successful immune restoration across China.
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spelling pubmed-61174192018-09-07 The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China Huang, Xiaojie Meyers, Kathrine Liu, Xinchao Li, Xia Zhang, Tong Xia, Wei Hou, Jiahua Song, Aixin He, Haolan Li, Chongxi He, Shenghua Cai, Weiping Zhong, Huolin Huang, Chengyu Liu, Shuiqing Wang, Hui Ling, Xuemei Ma, Ping Ye, Rongxia Xiao, Gang Li, Taisheng Ding, Ding Yaffe, Kristine Chen, Hui Chen, Yaokai Wu, Hao Front Psychiatry Psychiatry Background: Anxiety and depression continue to be significant comorbidities for people with HIV infection. We investigated the prevalence of and factors associated with anxiety and depression among adult HIV-infected patients across China. Methods: In this cross-sectional study, we described clinical and psychosocial variables related to depression and anxiety in 4103 HIV-infected persons. Doctors assessed anxiety and depression by asking patients whether they had experienced anxiety or depression in the prior month. Patients also self-administered the Hospital Anxiety and Depression (HAD) scale; those with score ≥8 on HAD-A/D were considered to be at high risk of anxiety or depression. Results: Associations between socio-demographic, psychosocial, and ART-related clinical factors and risk of depression or anxiety were investigated using multivariable logistic regression. Among patients assessed between 9/2014 and 11/2015, 27.4% had symptoms of anxiety, 32.9% had symptoms of depression, and 19.0% had both. Recentness of HIV diagnoses (P = 0.046) was associated with elevated odds of anxiety. Older age (P = 0.004), higher educational attainment (P < 0.001), employment (P = 0.001), support from family / friends (P < 0.001), and sleep disturbance (P < 0.001), and number of ART regimen switches (P = 0.046) were associated with risk of depression, while neither sex nor transmission route showed any associations. There were no significant associations with HIV-specific clinical factors including current CD4(+) T cell count and current viral load. Conclusions: Prevalence of symptoms of anxiety and depression is high in this cohort of treatment-experienced HIV patients. Psychological and social-demographic factors, rather than HIV disease status, were associated with risk of depression and anxiety. This finding highlights the need to deliver interventions to address the mental health issues affecting HIV-infected persons with fully successful immune restoration across China. Frontiers Media S.A. 2018-08-24 /pmc/articles/PMC6117419/ /pubmed/30197608 http://dx.doi.org/10.3389/fpsyt.2018.00384 Text en Copyright © 2018 Huang, Meyers, Liu, Li, Zhang, Xia, Hou, Song, He, Li, He, Cai, Zhong, Huang, Liu, Wang, Ling, Ma, Ye, Xiao, Li, Ding, Yaffe, Chen, Chen and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Huang, Xiaojie
Meyers, Kathrine
Liu, Xinchao
Li, Xia
Zhang, Tong
Xia, Wei
Hou, Jiahua
Song, Aixin
He, Haolan
Li, Chongxi
He, Shenghua
Cai, Weiping
Zhong, Huolin
Huang, Chengyu
Liu, Shuiqing
Wang, Hui
Ling, Xuemei
Ma, Ping
Ye, Rongxia
Xiao, Gang
Li, Taisheng
Ding, Ding
Yaffe, Kristine
Chen, Hui
Chen, Yaokai
Wu, Hao
The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China
title The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China
title_full The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China
title_fullStr The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China
title_full_unstemmed The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China
title_short The Double Burdens of Mental Health Among AIDS Patients With Fully Successful Immune Restoration: A Cross-Sectional Study of Anxiety and Depression in China
title_sort double burdens of mental health among aids patients with fully successful immune restoration: a cross-sectional study of anxiety and depression in china
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117419/
https://www.ncbi.nlm.nih.gov/pubmed/30197608
http://dx.doi.org/10.3389/fpsyt.2018.00384
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