Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion

Cysteine and glycine rich protein 3 (CSRP3) encodes Muscle LIM Protein (MLP), a well-established disease gene for Hypertrophic Cardiomyopathy (HCM). MLP, in contrast to the proteins encoded by the other recognised HCM disease genes, is non-sarcomeric, and has important signalling functions in cardio...

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Detalles Bibliográficos
Autores principales: Ehsan, Mehroz, Kelly, Matthew, Hooper, Charlotte, Yavari, Arash, Beglov, Julia, Bellahcene, Mohamed, Ghataorhe, Kirandeep, Poloni, Giulia, Goel, Anuj, Kyriakou, Theodosios, Fleischanderl, Karin, Ehler, Elisabeth, Makeyev, Eugene, Lange, Stephan, Ashrafian, Houman, Redwood, Charles, Davies, Benjamin, Watkins, Hugh, Gehmlich, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117453/
https://www.ncbi.nlm.nih.gov/pubmed/30048712
http://dx.doi.org/10.1016/j.yjmcc.2018.07.248

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