2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells

In this issue of Stem Cell Reports, Hastreiter et al. (2018) use continuous time-lapse imaging of mouse embryonic stem cells to investigate how the inhibition of GSK3b and MEK/ERK (2i) leads to homogeneous expression of the transcription factor Nanog. They show that both induction of Nanog expressio...

Descripción completa

Detalles Bibliográficos
Autor principal: Navarro, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117476/
https://www.ncbi.nlm.nih.gov/pubmed/29996086
http://dx.doi.org/10.1016/j.stemcr.2018.06.017
Descripción
Sumario:In this issue of Stem Cell Reports, Hastreiter et al. (2018) use continuous time-lapse imaging of mouse embryonic stem cells to investigate how the inhibition of GSK3b and MEK/ERK (2i) leads to homogeneous expression of the transcription factor Nanog. They show that both induction of Nanog expression and selection against cells expressing low levels of Nanog contribute to the homogeneous appearance of 2i cultures.

Ejemplares similares