2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells

In this issue of Stem Cell Reports, Hastreiter et al. (2018) use continuous time-lapse imaging of mouse embryonic stem cells to investigate how the inhibition of GSK3b and MEK/ERK (2i) leads to homogeneous expression of the transcription factor Nanog. They show that both induction of Nanog expressio...

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Detalles Bibliográficos
Autor principal: Navarro, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117476/
https://www.ncbi.nlm.nih.gov/pubmed/29996086
http://dx.doi.org/10.1016/j.stemcr.2018.06.017
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author Navarro, Pablo
author_facet Navarro, Pablo
author_sort Navarro, Pablo
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description In this issue of Stem Cell Reports, Hastreiter et al. (2018) use continuous time-lapse imaging of mouse embryonic stem cells to investigate how the inhibition of GSK3b and MEK/ERK (2i) leads to homogeneous expression of the transcription factor Nanog. They show that both induction of Nanog expression and selection against cells expressing low levels of Nanog contribute to the homogeneous appearance of 2i cultures.
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spelling pubmed-61174762018-08-31 2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells Navarro, Pablo Stem Cell Reports Preview In this issue of Stem Cell Reports, Hastreiter et al. (2018) use continuous time-lapse imaging of mouse embryonic stem cells to investigate how the inhibition of GSK3b and MEK/ERK (2i) leads to homogeneous expression of the transcription factor Nanog. They show that both induction of Nanog expression and selection against cells expressing low levels of Nanog contribute to the homogeneous appearance of 2i cultures. Elsevier 2018-07-10 /pmc/articles/PMC6117476/ /pubmed/29996086 http://dx.doi.org/10.1016/j.stemcr.2018.06.017 Text en © 2018 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Navarro, Pablo
2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells
title 2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells
title_full 2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells
title_fullStr 2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells
title_full_unstemmed 2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells
title_short 2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells
title_sort 2i, or not 2i: the soliloquy of nanog-negative mouse embryonic stem cells
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117476/
https://www.ncbi.nlm.nih.gov/pubmed/29996086
http://dx.doi.org/10.1016/j.stemcr.2018.06.017
work_keys_str_mv AT navarropablo 2iornot2ithesoliloquyofnanognegativemouseembryonicstemcells

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