Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer

Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies. Because chemokine network is involved in OC progression, we evaluated associations between chemokine expression and survival in tumor suppressor protein p53 (TP53) wild-type (TP53WT) and mutant (TP53m) OC datasets....

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Autores principales: Ignacio, Rosa Mistica C., Lee, Eun-Sook, Wilson, Andrew J., Beeghly-Fadiel, Alicia, Whalen, Margaret M., Son, Deok-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117514/
https://www.ncbi.nlm.nih.gov/pubmed/30181917
http://dx.doi.org/10.4110/in.2018.18.e29
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author Ignacio, Rosa Mistica C.
Lee, Eun-Sook
Wilson, Andrew J.
Beeghly-Fadiel, Alicia
Whalen, Margaret M.
Son, Deok-Soo
author_facet Ignacio, Rosa Mistica C.
Lee, Eun-Sook
Wilson, Andrew J.
Beeghly-Fadiel, Alicia
Whalen, Margaret M.
Son, Deok-Soo
author_sort Ignacio, Rosa Mistica C.
collection PubMed
description Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies. Because chemokine network is involved in OC progression, we evaluated associations between chemokine expression and survival in tumor suppressor protein p53 (TP53) wild-type (TP53WT) and mutant (TP53m) OC datasets. TP53 was highly mutated in OC compared to other cancer types. Among OC subtypes, CXCL14 was predominantly expressed in clear cell OC, and CCL15 and CCL20 in mucinous OC. TP53WT endometrioid OC highly expressed CXCL14 compared to TP53m, showing better progression-free survival but no difference in overall survival (OS). TP53m serous OC highly expressed CCL8, CCL20, CXCL10 and CXCL11 compared to TP53WT. CXCL12 and CCL21 were associated with poor OS in TP53WT serous OC. CXCR2 was associated with poor OS in TP53m serous OC, while CXCL9, CCL5, CXCR4, CXCL11, and CXCL13 were associated with better OS. Taken together, specific chemokine signatures may differentially influence OS in TP53WT and TP53m OC.
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spelling pubmed-61175142018-09-04 Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer Ignacio, Rosa Mistica C. Lee, Eun-Sook Wilson, Andrew J. Beeghly-Fadiel, Alicia Whalen, Margaret M. Son, Deok-Soo Immune Netw Brief Communication Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies. Because chemokine network is involved in OC progression, we evaluated associations between chemokine expression and survival in tumor suppressor protein p53 (TP53) wild-type (TP53WT) and mutant (TP53m) OC datasets. TP53 was highly mutated in OC compared to other cancer types. Among OC subtypes, CXCL14 was predominantly expressed in clear cell OC, and CCL15 and CCL20 in mucinous OC. TP53WT endometrioid OC highly expressed CXCL14 compared to TP53m, showing better progression-free survival but no difference in overall survival (OS). TP53m serous OC highly expressed CCL8, CCL20, CXCL10 and CXCL11 compared to TP53WT. CXCL12 and CCL21 were associated with poor OS in TP53WT serous OC. CXCR2 was associated with poor OS in TP53m serous OC, while CXCL9, CCL5, CXCR4, CXCL11, and CXCL13 were associated with better OS. Taken together, specific chemokine signatures may differentially influence OS in TP53WT and TP53m OC. The Korean Association of Immunologists 2018-08-13 /pmc/articles/PMC6117514/ /pubmed/30181917 http://dx.doi.org/10.4110/in.2018.18.e29 Text en Copyright © 2018. The Korean Association of Immunologists https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Ignacio, Rosa Mistica C.
Lee, Eun-Sook
Wilson, Andrew J.
Beeghly-Fadiel, Alicia
Whalen, Margaret M.
Son, Deok-Soo
Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer
title Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer
title_full Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer
title_fullStr Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer
title_full_unstemmed Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer
title_short Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer
title_sort chemokine network and overall survival in tp53 wild-type and mutant ovarian cancer
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117514/
https://www.ncbi.nlm.nih.gov/pubmed/30181917
http://dx.doi.org/10.4110/in.2018.18.e29
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