Cargando…

Clinical utility of arterial spin labeling for preoperative grading of glioma

There were obvious differences in biological behavior and prognosis between low- and high-grade gliomas, it is of great importance for clinicians to make a right judgement for preoperative grading. We conducted a comprehensive meta-analysis to evaluate the clinical utility of arterial spin labeling...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Jun, Li, Linchen, Wang, Xinjun, Zhang, Min, Zhang, Yan, Li, Zhanzhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117615/
https://www.ncbi.nlm.nih.gov/pubmed/29769414
http://dx.doi.org/10.1042/BSR20180507
_version_ 1783351785630466048
author Fu, Jun
Li, Linchen
Wang, Xinjun
Zhang, Min
Zhang, Yan
Li, Zhanzhan
author_facet Fu, Jun
Li, Linchen
Wang, Xinjun
Zhang, Min
Zhang, Yan
Li, Zhanzhan
author_sort Fu, Jun
collection PubMed
description There were obvious differences in biological behavior and prognosis between low- and high-grade gliomas, it is of great importance for clinicians to make a right judgement for preoperative grading. We conducted a comprehensive meta-analysis to evaluate the clinical utility of arterial spin labeling for preoperative grading. We searched the PubMed, Embase, China National Knowledge Infrastructure, and Weipu electronic databases for articles published through 10 November 2017 and used ‘arterial spin-labeling’ or ‘ASL perfusion, grading’ or ‘differentiation, glioma’ or ‘glial tumor, diagnostic test’ as the search terms. A manual search of relevant original and review articles was performed to identify additional studies. The meta-analysis included nine studies. No obvious heterogeneity was found in the data in a fixed-effect model. The pooled sensitivity and specificity were 90% (95% confidence interval (CI): 0.84–0.94) and 91% (95% CI: 0.83–0.96), respectively, and the pooled positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 10.40 (95% CI: 2.21–20.77) and 0.11 (95% CI: 0.07–0.18). The diagnostic odds ratio (DOR) was 92.47 (95% CI: 39.61–215.92). The diagnostic score was 4.53 (95% CI: 3.68–5.38). The area under the curve (AUC) was 0.94 (95% CI: 0.91–0.96). Subgroup analyses did not change the pooled results. No publication bias was found (P=0.102). The normalized maximal tumor blood flow/normal white matter ratio obtained with the arterial spin labeling technique was relatively accurate for distinguishing high/low-grade glioma. As a non-invasive procedure with favorable repeatability, this index may be useful for clinical diagnostics.
format Online
Article
Text
id pubmed-6117615
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-61176152018-09-10 Clinical utility of arterial spin labeling for preoperative grading of glioma Fu, Jun Li, Linchen Wang, Xinjun Zhang, Min Zhang, Yan Li, Zhanzhan Biosci Rep Research Articles There were obvious differences in biological behavior and prognosis between low- and high-grade gliomas, it is of great importance for clinicians to make a right judgement for preoperative grading. We conducted a comprehensive meta-analysis to evaluate the clinical utility of arterial spin labeling for preoperative grading. We searched the PubMed, Embase, China National Knowledge Infrastructure, and Weipu electronic databases for articles published through 10 November 2017 and used ‘arterial spin-labeling’ or ‘ASL perfusion, grading’ or ‘differentiation, glioma’ or ‘glial tumor, diagnostic test’ as the search terms. A manual search of relevant original and review articles was performed to identify additional studies. The meta-analysis included nine studies. No obvious heterogeneity was found in the data in a fixed-effect model. The pooled sensitivity and specificity were 90% (95% confidence interval (CI): 0.84–0.94) and 91% (95% CI: 0.83–0.96), respectively, and the pooled positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 10.40 (95% CI: 2.21–20.77) and 0.11 (95% CI: 0.07–0.18). The diagnostic odds ratio (DOR) was 92.47 (95% CI: 39.61–215.92). The diagnostic score was 4.53 (95% CI: 3.68–5.38). The area under the curve (AUC) was 0.94 (95% CI: 0.91–0.96). Subgroup analyses did not change the pooled results. No publication bias was found (P=0.102). The normalized maximal tumor blood flow/normal white matter ratio obtained with the arterial spin labeling technique was relatively accurate for distinguishing high/low-grade glioma. As a non-invasive procedure with favorable repeatability, this index may be useful for clinical diagnostics. Portland Press Ltd. 2018-08-31 /pmc/articles/PMC6117615/ /pubmed/29769414 http://dx.doi.org/10.1042/BSR20180507 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Fu, Jun
Li, Linchen
Wang, Xinjun
Zhang, Min
Zhang, Yan
Li, Zhanzhan
Clinical utility of arterial spin labeling for preoperative grading of glioma
title Clinical utility of arterial spin labeling for preoperative grading of glioma
title_full Clinical utility of arterial spin labeling for preoperative grading of glioma
title_fullStr Clinical utility of arterial spin labeling for preoperative grading of glioma
title_full_unstemmed Clinical utility of arterial spin labeling for preoperative grading of glioma
title_short Clinical utility of arterial spin labeling for preoperative grading of glioma
title_sort clinical utility of arterial spin labeling for preoperative grading of glioma
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117615/
https://www.ncbi.nlm.nih.gov/pubmed/29769414
http://dx.doi.org/10.1042/BSR20180507
work_keys_str_mv AT fujun clinicalutilityofarterialspinlabelingforpreoperativegradingofglioma
AT lilinchen clinicalutilityofarterialspinlabelingforpreoperativegradingofglioma
AT wangxinjun clinicalutilityofarterialspinlabelingforpreoperativegradingofglioma
AT zhangmin clinicalutilityofarterialspinlabelingforpreoperativegradingofglioma
AT zhangyan clinicalutilityofarterialspinlabelingforpreoperativegradingofglioma
AT lizhanzhan clinicalutilityofarterialspinlabelingforpreoperativegradingofglioma