Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis

Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6–14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectra...

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Autores principales: Wu, Chia-Hua, Chao, Chih-Hua, Huang, Tzu-Zin, Huang, Chiung-Yao, Hwang, Tsong-Long, Dai, Chang-Feng, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117644/
https://www.ncbi.nlm.nih.gov/pubmed/30096866
http://dx.doi.org/10.3390/md16080278
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author Wu, Chia-Hua
Chao, Chih-Hua
Huang, Tzu-Zin
Huang, Chiung-Yao
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
author_facet Wu, Chia-Hua
Chao, Chih-Hua
Huang, Tzu-Zin
Huang, Chiung-Yao
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
author_sort Wu, Chia-Hua
collection PubMed
description Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6–14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inflammatory activities of the isolates were investigated, and the results showed that dehydrosinulariolide (7) and 11-epi-sinulariolide acetate (8) exhibited cytotoxicity toward a limited panel of cancer cell lines and 14-deoxycrassin (9) displayed anti-inflammatory activity by inhibition of superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils.
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spelling pubmed-61176442018-09-05 Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis Wu, Chia-Hua Chao, Chih-Hua Huang, Tzu-Zin Huang, Chiung-Yao Hwang, Tsong-Long Dai, Chang-Feng Sheu, Jyh-Horng Mar Drugs Article Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6–14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inflammatory activities of the isolates were investigated, and the results showed that dehydrosinulariolide (7) and 11-epi-sinulariolide acetate (8) exhibited cytotoxicity toward a limited panel of cancer cell lines and 14-deoxycrassin (9) displayed anti-inflammatory activity by inhibition of superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils. MDPI 2018-08-09 /pmc/articles/PMC6117644/ /pubmed/30096866 http://dx.doi.org/10.3390/md16080278 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Chia-Hua
Chao, Chih-Hua
Huang, Tzu-Zin
Huang, Chiung-Yao
Hwang, Tsong-Long
Dai, Chang-Feng
Sheu, Jyh-Horng
Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis
title Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis
title_full Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis
title_fullStr Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis
title_full_unstemmed Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis
title_short Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis
title_sort cembranoid-related metabolites and biological activities from the soft coral sinularia flexibilis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117644/
https://www.ncbi.nlm.nih.gov/pubmed/30096866
http://dx.doi.org/10.3390/md16080278
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