New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation

New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showi...

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Autores principales: Carbone, Anna, Parrino, Barbara, Cusimano, Maria Grazia, Spanò, Virginia, Montalbano, Alessandra, Barraja, Paola, Schillaci, Domenico, Cirrincione, Girolamo, Diana, Patrizia, Cascioferro, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117647/
https://www.ncbi.nlm.nih.gov/pubmed/30081568
http://dx.doi.org/10.3390/md16080274
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author Carbone, Anna
Parrino, Barbara
Cusimano, Maria Grazia
Spanò, Virginia
Montalbano, Alessandra
Barraja, Paola
Schillaci, Domenico
Cirrincione, Girolamo
Diana, Patrizia
Cascioferro, Stella
author_facet Carbone, Anna
Parrino, Barbara
Cusimano, Maria Grazia
Spanò, Virginia
Montalbano, Alessandra
Barraja, Paola
Schillaci, Domenico
Cirrincione, Girolamo
Diana, Patrizia
Cascioferro, Stella
author_sort Carbone, Anna
collection PubMed
description New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC(50) values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed a typical anti-virulence profile, being able to inhibit the biofilm formation without affecting the microbial growth in the planktonic form.
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spelling pubmed-61176472018-09-05 New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation Carbone, Anna Parrino, Barbara Cusimano, Maria Grazia Spanò, Virginia Montalbano, Alessandra Barraja, Paola Schillaci, Domenico Cirrincione, Girolamo Diana, Patrizia Cascioferro, Stella Mar Drugs Article New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC(50) values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed a typical anti-virulence profile, being able to inhibit the biofilm formation without affecting the microbial growth in the planktonic form. MDPI 2018-08-04 /pmc/articles/PMC6117647/ /pubmed/30081568 http://dx.doi.org/10.3390/md16080274 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carbone, Anna
Parrino, Barbara
Cusimano, Maria Grazia
Spanò, Virginia
Montalbano, Alessandra
Barraja, Paola
Schillaci, Domenico
Cirrincione, Girolamo
Diana, Patrizia
Cascioferro, Stella
New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
title New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
title_full New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
title_fullStr New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
title_full_unstemmed New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
title_short New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
title_sort new thiazole nortopsentin analogues inhibit bacterial biofilm formation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117647/
https://www.ncbi.nlm.nih.gov/pubmed/30081568
http://dx.doi.org/10.3390/md16080274
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