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Antimicrobial Porous Surfaces Prepared by Breath Figures Approach

Herein, efficient antimicrobial porous surfaces were prepared by breath figures approach from polymer solutions containing low content of block copolymers with high positive charge density. In brief, those block copolymers, which were used as additives, are composed of a polystyrene segment and a la...

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Autores principales: Muñoz-Bonilla, Alexandra, Cuervo-Rodríguez, Rocío, López-Fabal, Fátima, Gómez-Garcés, José L., Fernández-García, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117655/
https://www.ncbi.nlm.nih.gov/pubmed/30042299
http://dx.doi.org/10.3390/ma11081266
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author Muñoz-Bonilla, Alexandra
Cuervo-Rodríguez, Rocío
López-Fabal, Fátima
Gómez-Garcés, José L.
Fernández-García, Marta
author_facet Muñoz-Bonilla, Alexandra
Cuervo-Rodríguez, Rocío
López-Fabal, Fátima
Gómez-Garcés, José L.
Fernández-García, Marta
author_sort Muñoz-Bonilla, Alexandra
collection PubMed
description Herein, efficient antimicrobial porous surfaces were prepared by breath figures approach from polymer solutions containing low content of block copolymers with high positive charge density. In brief, those block copolymers, which were used as additives, are composed of a polystyrene segment and a large antimicrobial block bearing flexible side chain with 1,3-thiazolium and 1,2,3-triazolium groups, PS(54)-b-PTTBM-M(44), PS(54)-b-PTTBM-B(44), having different alkyl groups, methyl or butyl, respectively. The antimicrobial block copolymers were blended with commercial polystyrene in very low proportions, from 3 to 9 wt %, and solubilized in THF. From these solutions, ordered porous films functionalized with antimicrobial cationic copolymers were fabricated, and the influence of alkylating agent and the amount of copolymer in the blend was investigated. Narrow pore size distribution was obtained for all the samples with pore diameters between 5 and 11 µm. The size of the pore decreased as the hydrophilicity of the system increased; thus, either as the content of copolymer was augmented in the blend or as the copolymers were quaternized with methyl iodide. The resulting porous polystyrene surfaces functionalized with low content of antimicrobial copolymers exhibited remarkable antibacterial efficiencies against Gram positive bacteria Staphylococcus aureus, and Candida parapsilosis fungi as microbial models.
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spelling pubmed-61176552018-09-05 Antimicrobial Porous Surfaces Prepared by Breath Figures Approach Muñoz-Bonilla, Alexandra Cuervo-Rodríguez, Rocío López-Fabal, Fátima Gómez-Garcés, José L. Fernández-García, Marta Materials (Basel) Article Herein, efficient antimicrobial porous surfaces were prepared by breath figures approach from polymer solutions containing low content of block copolymers with high positive charge density. In brief, those block copolymers, which were used as additives, are composed of a polystyrene segment and a large antimicrobial block bearing flexible side chain with 1,3-thiazolium and 1,2,3-triazolium groups, PS(54)-b-PTTBM-M(44), PS(54)-b-PTTBM-B(44), having different alkyl groups, methyl or butyl, respectively. The antimicrobial block copolymers were blended with commercial polystyrene in very low proportions, from 3 to 9 wt %, and solubilized in THF. From these solutions, ordered porous films functionalized with antimicrobial cationic copolymers were fabricated, and the influence of alkylating agent and the amount of copolymer in the blend was investigated. Narrow pore size distribution was obtained for all the samples with pore diameters between 5 and 11 µm. The size of the pore decreased as the hydrophilicity of the system increased; thus, either as the content of copolymer was augmented in the blend or as the copolymers were quaternized with methyl iodide. The resulting porous polystyrene surfaces functionalized with low content of antimicrobial copolymers exhibited remarkable antibacterial efficiencies against Gram positive bacteria Staphylococcus aureus, and Candida parapsilosis fungi as microbial models. MDPI 2018-07-24 /pmc/articles/PMC6117655/ /pubmed/30042299 http://dx.doi.org/10.3390/ma11081266 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Muñoz-Bonilla, Alexandra
Cuervo-Rodríguez, Rocío
López-Fabal, Fátima
Gómez-Garcés, José L.
Fernández-García, Marta
Antimicrobial Porous Surfaces Prepared by Breath Figures Approach
title Antimicrobial Porous Surfaces Prepared by Breath Figures Approach
title_full Antimicrobial Porous Surfaces Prepared by Breath Figures Approach
title_fullStr Antimicrobial Porous Surfaces Prepared by Breath Figures Approach
title_full_unstemmed Antimicrobial Porous Surfaces Prepared by Breath Figures Approach
title_short Antimicrobial Porous Surfaces Prepared by Breath Figures Approach
title_sort antimicrobial porous surfaces prepared by breath figures approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117655/
https://www.ncbi.nlm.nih.gov/pubmed/30042299
http://dx.doi.org/10.3390/ma11081266
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