New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164

Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic ana...

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Detalles Bibliográficos
Autores principales: Fan, Yaqin, Wang, Cong, Wang, Liping, Chairoungdua, Arthit, Piyachaturawat, Pawinee, Fu, Peng, Zhu, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117703/
https://www.ncbi.nlm.nih.gov/pubmed/30111735
http://dx.doi.org/10.3390/md16080282
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author Fan, Yaqin
Wang, Cong
Wang, Liping
Chairoungdua, Arthit
Piyachaturawat, Pawinee
Fu, Peng
Zhu, Weiming
author_facet Fan, Yaqin
Wang, Cong
Wang, Liping
Chairoungdua, Arthit
Piyachaturawat, Pawinee
Fu, Peng
Zhu, Weiming
author_sort Fan, Yaqin
collection PubMed
description Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC(50) values of 15 and 23 μM, respectively.
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spelling pubmed-61177032018-09-05 New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164 Fan, Yaqin Wang, Cong Wang, Liping Chairoungdua, Arthit Piyachaturawat, Pawinee Fu, Peng Zhu, Weiming Mar Drugs Communication Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC(50) values of 15 and 23 μM, respectively. MDPI 2018-08-15 /pmc/articles/PMC6117703/ /pubmed/30111735 http://dx.doi.org/10.3390/md16080282 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Fan, Yaqin
Wang, Cong
Wang, Liping
Chairoungdua, Arthit
Piyachaturawat, Pawinee
Fu, Peng
Zhu, Weiming
New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164
title New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164
title_full New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164
title_fullStr New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164
title_full_unstemmed New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164
title_short New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164
title_sort new ansamycins from the deep-sea-derived bacterium ochrobactrum sp. oucmdz-2164
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117703/
https://www.ncbi.nlm.nih.gov/pubmed/30111735
http://dx.doi.org/10.3390/md16080282
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